Threshold of Chronic Action

The chronic threshold (or limch) is an important term in the field of pharmacology and medicine that describes the minimum amount of drug required to achieve a therapeutic effect.

Unlike acute action, which is usually expressed in a short but strong effect, chronic action means a long-term, gradual manifestation of the drug in the body. When forming a threshold for chronic action, the researcher determines the maximum amount of the active substance at which the desired effect is maintained during long-term use. This is important to understand how the drug will work in a person's daily life, as well as to determine the minimum effective dose. The chronicity threshold is especially important in the case of new drugs or treatments for chronic diseases such as diabetes, cardiovascular disease and cancer. For new drugs, it is important to find out what dose is needed to maintain effective treatment over the long term. In the treatment of chronic diseases, it is important to determine what minimum amount of medication is needed to ensure maximum effectiveness while minimizing possible side effects.