Thrombokinase

Thrombokinase is an enzyme that plays an important role in the blood clotting process. It is one of the key factors involved in the formation of blood clots. Thrombin, which is formed as a result of activation of thrombokinase, plays a key role in blood clotting by converting fibrinogen into fibrin.

Thrombokinase is an intracellular enzyme found in endothelial cells, liver cells and platelets. When these cells are damaged, such as by injury or inflammation, thrombokinase is activated and begins the process of blood clotting.

The process of thrombokinase activation includes several stages. First, a complex called thromboplastin is formed on the cell surface, which binds to thrombokinase. Thrombokinase then binds to form a complex with thrombin. This leads to the activation of thrombokinase and the formation of thrombin.

It is important to note that activation of thrombokinase occurs only in response to cell damage. If the cells are not damaged, thrombokinase remains inactive and does not participate in the blood clotting process.

Thrombokinase (also known as thrombinase) is an enzyme that plays an important role in blood clot formation and inflammation. This protein is found in the blood and lymph fluid, as well as in organ tissue.

Thrombinogenases are located mainly in the cytolytic (VWF = von Willeband factor), platelet and macrophage components of hemostasis. Their main significance is that they direct platelets from the bloodstream of vessels into atheromas.

Here, thrombogenases convert the inactive precursor prothrombin into the active enzyme thrombin. The mechanism of inclusion of this molecule in thrombogenesis occurs as an entangling sequence with several steps. In the first two steps, thromboplastin, a soluble carrier of the thrombogenic enzyme Fhrombokinase (IXa), is released from the active enzyme FVIII. The final stage in the transformation of tissue factor Fibrin is the formation of thrombin. It breaks down the protein, lipid and mineral components of the molecules and at the same time creates a new Fibrin compound around the area of ​​​​damaged tissue, which strengthens it and prevents bleeding.