Thiopental-Kmp

forms and composition

Thiopental-KMP is a lyophilized powder for the preparation of an injection solution and contains sodium thiopental as an active ingredient. The drug is produced in Ukraine by the Kievmedpreparat company.

Indications for use

Thiopental-KMP is used for induction and maintenance of short-term general anesthesia during surgical interventions, as well as for sedation for status epilepticus, seizures, increased intracranial pressure, and the prevention of brain hypoxia in traumatic brain injuries.

Contraindications

The drug is contraindicated in case of hypersensitivity to Thiopental or other barbiturates, bronchial asthma, status asthmaticus, liver and kidney dysfunction, impaired myocardial contractile function, severe anemia, shock and collaptoid conditions, myasthenia gravis, myxedema, Addison's disease, fever, inflammatory diseases of the nasopharynx, porphyria and pregnancy .

Side effects

Thiopental-CM may cause various side effects, including arrhythmia, hypotension, respiratory depression or arrest, laryngospasm, bronchospasm, nausea, vomiting, drowsiness, headache, chills, heart failure, rectal irritation and bleeding (with rectal administration), allergic reactions: urticaria, skin rashes and itching, anaphylactic shock.

Interaction with other drugs

Thiopental-CMP can enhance the effect of antihypertensive and hypothermic drugs, depress the central nervous system under the influence of alcohol, sedatives, hypnotics, ketamine, antipsychotics, magnesium sulfate. The activity of the drug increases when used simultaneously with probenecid and H1-blockers, and is weakened when using aminophylline, analeptics and some antidepressants. Thiopental-CMP is pharmaceutically incompatible with antibiotics (amikacin, benzylpenicillin, cephapirin), tranquilizers, muscle relaxants (suxamethonium, tubocurarine), analgesics (codeine), ephedrine, ascorbic acid, dipyridamole, chlorpromazine and ketamine.

Overdose and treatment

An overdose of Thiopental-KMP can lead to respiratory depression to the point of arrest, decreased blood pressure, heart failure, coma and death. Treatment of overdose includes discontinuation of the drug, mechanical ventilation, cardiotonic therapy, and saline infusion.