Tumor Transplantable

A continuous tumor is an experimental tumor that can be transferred from one animal to another. At the same time, tumor growth is preserved and continues in the recipient’s body, which makes it possible to conduct research on animal models.

Continuous tumor is an important tool for studying cancer and its treatment. It allows scientists to study the mechanism of tumor development, its sensitivity to various types of treatment, and the effectiveness of new treatments. In addition, it can help in the development of new drugs and cancer treatments.

However, the use of continuous tumors has its limitations. First, when tumor cells are transferred from one animal to another, problems may arise with the recipient's immune response to foreign cells. This can lead to the development of an immune response and the death of the animal.

Secondly, a continuous tumor may not reflect all aspects of cancer development in the human body. This is because tumor cells may differ from human cancer cells in their characteristics and behavior.

However, the use of transplantable tumors is an important tool in the study of cancer and the development of new methods of treating it.

Transplantable tumors (experimental tumors) are lines of tumor cells of various origins obtained by transplanting primary tumor cells into the recipient's body - animal or human. Penetration of a tumor into the latter’s body or its re-entry (inoculation) leads to tumor growth in the conditions of a new organism, which makes it possible to use such lines for studying the properties of tumors in vivo and for experiments on chemotherapy and other types of antitumor therapy. In this context, these tumors play the role of a vaccine, which in the case of cancer will help to get rid of it more easily. Similar experiments began in the West in the 70s. XX century The following methods of introducing tumors to animals were used: . subcutaneous transplantation (Claudis method, 1971); . intravenous injections of a suspension of tumor cells; . transplantation of a tumor implant under the skin. Such methods make it possible to identify the first signs of the adverse effects of a tumor and study the individual effect of various antitumor drugs, as well as antibiotics. Tumors can be used as a target for the production of antibodies against tumors. Therefore, female mice are infected with a tumor, then the presence of a tumor is detected and the transplantation is repeated three times, then an immune response to it is formed. Such tumor strains are actively proliferative. The resulting tumor cultures are mainly quiescent (hypostasis) cells, which multiply after activation by blast cell extracts, serums, injectable vaccines, etc. Activation is aimed at the union of diploid parent cells and sexual daughter cells, and the subsequent reproduction of all these cells. However, sometimes primary tumor explants can be found; they proliferate actively. From the primary explants of isolated tumors, two groups can be distinguished: cells with an autonomous type of proliferation, producing a large amount of poisons that act in contact on the recipient cells and inhibit the proliferation of tumor and healthy cells; explant (cultured) cells do not have these properties; they reproduce by differentiating into decent populations with fewer poisons. Explant cells