The Addis urea coefficient (urea index) is an indicator that is used to assess kidney function in patients with chronic renal failure. This ratio is calculated based on the level of urea in the blood and creatinine in the urine.
Urea is a breakdown product of proteins in the body, which is excreted through the kidneys. If the kidneys cannot completely remove urea from the blood, the level of urea in the blood increases. This may be associated with various kidney diseases, such as glomerulonephritis, pyelonephritis, hydronephrosis, etc.
Creatinine is a substance that is formed in the muscles during physical activity and is then excreted through the kidneys. Blood creatinine levels may also increase with kidney disease.
To calculate the Addis urea ratio, it is necessary to measure the level of urea and creatinine in the patient's blood and urine. The ratio of urea level to creatinine level is then calculated. If this ratio is greater than 10, it means the kidneys are not functioning properly and further testing and treatment is required.
Overall, the Addis urea ratio is an important indicator for assessing kidney function and can help in the diagnosis and treatment of kidney diseases. However, to obtain accurate results, it is necessary to correctly measure and interpret the results.