Fatigue Muscular Pathological

Pathological muscle fatigue is the accelerated development of muscle fatigue, which is observed in myasthenia gravis.

Myasthenia gravis is an autoimmune disease in which the transmission of nerve impulses from motor nerves to muscles is disrupted. This leads to pathological muscle weakness and rapid muscle fatigue during physical activity.

The main symptoms of pathological muscle fatigue:

1. Increased muscle weakness during exercise, which goes away after rest. For example, when climbing stairs or carrying heavy objects.

2. Increasing ptosis of the eyelids (drooping of the upper eyelids) throughout the day.

3. Diplopia (double vision) with prolonged visual strain.

4. Weakening of facial muscles and masticatory muscles. Difficulty chewing, swallowing, speaking.

5. Weakness of the muscles of the neck, shoulder girdle, trunk and limbs.

Diagnosis of pathological muscle fatigue is based on the analysis of complaints, EMG data, stimulation tests with the administration of anticholinesterase drugs. Treatment includes drug therapy, physical therapy, and exercise therapy.

Fatigue Muscular Pathological: Relationship with Myasthenia Gravis

Myasthenia gravis, a chronic autoimmune disease, is often accompanied by muscle fatigue. Pathological muscle fatigue is the accelerated development of muscle fatigue and is one of the characteristic clinical manifestations of myasthenia gravis. In this article we will look at the connection between muscle fatigue and myasthenia gravis, as well as the main aspects of pathological muscle fatigue.

Myasthenia gravis is an autoimmune disease in which the body's immune system attacks acetylcholine receptors on the surface of muscles. This leads to disruption of the transmission of neuromuscular impulses and muscle weakness. However, one of the most characteristic symptoms of myasthenia gravis is muscle fatigue, which is different from normal physiological fatigue.

Pathological muscle fatigue manifests itself in the form of a rapid increase in muscle fatigue when performing repetitive movements or efforts. Patients with myasthenia gravis often notice that their muscles become weak and less able to contract after mild physical exertion. This may limit their ability to carry out daily tasks and activities.

The cause of muscle fatigue in myasthenia gravis is associated with dysfunction of neuromuscular transmission. Under normal conditions, a nerve impulse causes the release of acetylcholine into the synaptic cleft, where it binds to receptors on the surface of the muscles and causes them to contract. However, in myasthenia gravis, due to an autoimmune attack on acetylcholine receptors, the number of available receptors is reduced. This results in less acetylcholine available to activate muscles, resulting in poor muscle function and fatigue.

Diagnosis of pathological muscle fatigue is based on an assessment of symptoms and the results of special laboratory tests, such as electromyography and muscle fatigue tests. Treatment of myasthenia gravis is aimed at reducing symptoms and controlling the autoimmune process. Doctors may prescribe drugs that improve neuromuscular transmission, immunomodulators, and other treatments.

In conclusion, pathological muscle fatigue is a characteristic feature of myasthenia gravis. Patients with this condition experience an accelerated development of muscle fatigue with repetitive movements or physical activity. Pathological muscle fatigue is explained by disruption of neuromuscular transmission due to an autoimmune attack on acetylcholine receptors. To diagnose and treat pathological muscle fatigue, timely consultation with a doctor, conducting the necessary studies and prescribing appropriate therapy is important. Understanding the connection between muscle fatigue and myasthenia gravis helps improve the management of this condition and improve the quality of life of patients.