Vancomycin

icin pathogens, with ineffectiveness and intolerance to penicillins, cephalosporins and other antibiotics. Such diseases include sepsis, endocarditis, pneumonia, lung abscess, osteomyelitis, infections of the skin and skin structures, pseudomembranous colitis caused by Clostridium difficile, enterocolitis and meningitis.

Vancomycin is an antibiotic that is produced in Israel by Teva Pharmaceutical Enterprises Ltd. It belongs to the group of antibiotics of different groups and is an effective remedy for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to it.

The dosage form of Vancomycin is presented as a lyophilized powder for the preparation of an intravenous solution of 1000 mg. Active ingredient: Vancomycin.

Vancomycin has a number of contraindications. It is not recommended for use in case of hypersensitivity to the active substance, auditory neuritis and in the first trimester of pregnancy. There are also restrictions for use in cases of severe kidney damage, hearing impairment, pregnancy in the second and third trimesters, as well as breastfeeding.

Vancomycin has a number of side effects that may include nausea, vomiting, bitter taste in the mouth, chills, itchy skin, hives, and Stevens-Johnson syndrome. After intravenous administration, thrombophlebitis, vasculitis, fever, neutropenia, eosinophilia, thrombocytopenia and anaphylactoid reactions may occur. Rapid intravenous administration may cause a burning sensation, redness of the upper body (red neck syndrome), pain and muscle spasms in the back and chest, arterial hypotension, dizziness, and tinnitus. In rare cases, oto- and nephrotoxic effects may occur.

When Vancomycin is combined with aminoglycosides, amphotericin B, bacitracin, loop diuretics, cisplatin, cyclosporine, polymyxins, the risk of hearing loss and kidney damage increases. Cholestyramine reduces the effectiveness of the drug. Concomitant use with general anesthetics can lead to the development of erythema, histamine-like hot flashes and arterial hypotension.

Vancomycin should be used only under the supervision of a physician, who must evaluate the indications for its use, select the required dose and duration of treatment. In addition, to prevent the development of resistance of microorganisms to Vancomycin, it is necessary to strictly follow the recommendations for its use and not exceed the recommended doses.

In general, vancomycin is an effective antibiotic for the treatment of severe infections caused by susceptible microorganisms. However, its use should be limited to a physician who must evaluate the risks and side effects and determine the most effective course of treatment.