Vero-Anaprilin

Country of origin: Russia
Pharm-Group: Beta-blockers (non-cardioselective)

Manufacturers: Veropharm/Belgorod branch (Russia)
International name: Propranolol
Synonyms: Anaprilin, Apo-Propranolol, Betake TR, Inderal, Inderal LA, Indicardin, Novo-Pranol, Obzidan, PMS-propranolol, Prolol, Propra-Ratiopharm, Propranobene, Propranolol, Propranolol Nycomed
Dosage forms: tablets 40 mg
Composition: Active ingredient - propranolol.

Indications for use: Arterial hypertension, angina pectoris, sinus tachycardia (including with hyperthyroidism), supraventricular tachycardia, tachysystolic form of atrial fibrillation, supraventricular and ventricular extrasystole, hypertrophic cardiomyopathy, myocardial infarction, mitral valve prolapse, subaortic stenosis, sympathoadrenal crisis patients with diencephalic syndrome, neurocirculatory dystonia, portal hypertension, essential tremor, panic attacks, aggressive behavior, migraine (prevention), auxiliary treatment for pheochromocytoma (only in combination with alpha-blockers), thyrotoxicosis (including preoperative preparation), thyrotoxicosis crisis, primary weakness of labor, menopausal vasomotor symptoms, withdrawal syndrome; treatment of akathisia caused by neuroleptics.

Contraindications: Hypersensitivity, AV block II-III degree, sinoatrial block, bradycardia (less than 55 beats/min), sick sinus syndrome, arterial hypotension, acute and severe chronic heart failure, Prinzmetal's angina, cardiogenic shock, occlusive vascular diseases, bronchial asthma. Breastfeeding should be stopped during treatment. Restrictions on use: Chronic bronchitis, emphysema, diabetes mellitus, hypoglycemia, acidosis, impaired liver and kidney function, psoriasis, spastic colitis, myasthenia gravis, old age. Use during pregnancy and breastfeeding: Possible if the expected effect of therapy exceeds the potential risk to the fetus.

Side effects: From the cardiovascular system and blood (hematopoiesis, hemostasis): bradycardia, heart failure, AV block, hypotension, peripheral circulatory disorders, thrombocytopenic purpura, leukopenia, agranulocytosis. From the nervous system and sensory organs: asthenia, dizziness, headache, insomnia, drowsiness, nightmares, decreased speed of mental and motor reactions, emotional lability, depression, agitation, hallucinations, disorientation in time and space, short-term amnesia, sensory disturbances, paresthesia; dry eyes, visual disturbances, keratoconjunctivitis. From the gastrointestinal tract: nausea, vomiting, abdominal pain, diarrhea or constipation, mesenteric artery thrombosis, ischemic colitis. From the respiratory system: pharyngitis, chest pain, cough, shortness of breath, broncho- and laryngospasm, respiratory distress syndrome. From the skin: alopecia, rash, itching, exacerbation of psoriasis. Other: withdrawal syndrome, decreased libido, impotence, Peyronie's disease, arthralgia, allergic reactions, lupus syndrome, hypoglycemia, fever.

Interaction: Strengthens (mutually) the negative effect of verapamil and diltiazem on the myocardium, prolongs the action of non-depolarizing muscle relaxants, and inhibits the elimination of lidocaine. They weaken the hypotensive effect of NSAIDs, glucocorticoids, estrogens, cocaine; enhance - nitrates and other antihypertensive drugs. Heparin and antacids reduce plasma levels; cimetidine and phenothiazines - increase. Concomitant use with MAO inhibitors is not recommended. Slows down the metabolism of theophylline and increases its concentration in the blood plasma.