Allogeneic

Allogeneic (from the Greek ἄλλος - other and γένος - kind) is a term used to describe a graft obtained from a donor of the same biological species as the recipient, but with a different histocompatibility.

Allogeneic transplants are taken from a donor who is genetically different from the recipient, in contrast to autologous transplants, where the donor is the patient himself. Examples of allogeneic transplants include bone marrow, stem cell, or organ transplants from a non-identical donor.

Because the genetic material of the donor and recipient is different, there is a high risk of immune rejection of the allogeneic transplant. To prevent this, careful selection of an HLA-compatible donor and immunosuppressive therapy for the recipient are carried out. Despite the risks, allogeneic transplants are widely used in medicine due to the availability of suitable donors.

Allogeneic transplantation is a treatment method in which an organ or tissue is transplanted into a patient from a donor who has a different blood type and different immune characteristics. This method has a number of advantages compared to autogenous transplantation, when an organ or tissue is transplanted from the patient himself. In particular, allogeneic transplantation can be used to treat rare diseases such as hemophilia or blood cancer.

To receive an allogeneic transplant, it is necessary to find a donor with a suitable blood type and immune system. For this purpose, special databases are used that contain information about potential donors.

Once a donor has been found, the organ or tissue collection procedure is carried out. This is usually done in an operating room, where a surgeon performs surgery on the donor and removes the desired organ or tissue. The organ or tissue is then transported to an organ bank, where it is stored until a suitable recipient is found.

The recipient also undergoes an organ or tissue retrieval procedure, after which the organ or tissue is inserted into the recipient's body. After the transplant, the patient takes immunosuppressive medications to prevent organ or tissue rejection and to maintain compatibility between the recipient and donor's immune systems.

Overall, an allogeneic graft has several advantages over an autogenous graft, including a higher likelihood of treatment success and the ability to be used to treat rare and complex diseases. However, this method also carries a risk of rejection and complications, so it should only be performed under the supervision of experienced professionals.

**Allogeneic transplants or allografts**, as they are often called in science, are made from organs and tissues of other people. This method is called allogeneic organ or tissue transplantation. To be precise, this is called tissue from a living person to another person, that is, an unrelated transplant. Donors and recipients are not related. There is also a technology for allogeneic organ transplantation using modified cells obtained from other donors 1 .

Doctors can then use such materials to create tissue grafts to further treat many diseases in sick people. The most common form of allogeneic transplantation currently is bone marrow transplantation, which is used to treat leukemia and other hematopoietic disorders in children and adults.

Another type of allogeneic transplantation involves using plasma from women. This helps stabilize blood pressure during surgery. Plasma injections are given immediately before surgery and help control blood pressure in patients with chronic heart failure.

** Allegone**

**(from ancient Greek ἄλλος - another, special, outsider and γεννάω - I give birth, I produce)** - used to describe the properties of drugs that provide

biochemical or immunological effects on the body. "Allergenicity" may be

caused by the presence in the structure of the substance of substances that cause allergies, also during vaccination. Vaccination that has a harmless effect on people with immunopathology