Anaphylactic Reaction

Anaphylactic shock is one of the most dangerous delayed-type hypersensitivity reactions. In anaphylactic shock, the cause of the reaction is not known; due to this fact, the use of the term “cold (antonym to heat) shock” was even proposed. The main manifestation of the condition is a sharp drop in blood pressure up to coma, acute circulatory failure caused by impaired microcirculation in the pulmonary circulation. Up to 5% of allergic reactions result in death. These conditions develop faster than urticaria and Quincke's edema.

Pathogenesis The cause of anaphylactic shock is the repeated entry into the human body of a certain allergen, for example, when administering serums, vaccines, taking medications, etc. The repeated entry of the antigen triggers a cascade of reactions - the antigen interacts with the antigen-presenting cell, an antigen-antibody reaction occurs, then an antigen-antibody complex is formed and this complex is cleaved, activating various cells - mast cells, basophils, neutrophils and eosinophils (histamines, proteinases, peroxidases and others ). This is how sensitization occurs, a state of increased sensitivity in response to repeated contact with an antigenic substance. Sensitivity