Country of origin: Italy
Pharm-Group: Calcium channel blockers of the dihydropyridine group
Manufacturers: Laboratory Giorgio Zoya (Italy)
International name: Nifedipine
Synonyms: Adalat, Adalat SL, Apo-Nifed, Vero-Nifedipine, Hypernal, Hypernal 10, Hypernal 5, Hypernal drops, Depin-E, Calcigard, Calcigard retard, Calcigard-10, Calcigard-5, Karin-Fer, Cordafen, Cordaflex , Cordaflex RD, Cordipin, Cordipin XL, Cordipin HL, Cordi
Dosage forms: gelatin capsules 10 mg, retard tablets 20 mg
Composition: Active substance - nifedipine.
Indications for use: Arterial hypertension, including hypertensive crisis, prevention of angina attacks (including Prinzmetal's angina), hypertrophic cardiomyopathy (obstructive, etc.), Raynaud's disease, pulmonary hypertension, broncho-obstructive syndrome.
Contraindications: Hypersensitivity, acute period of myocardial infarction (first 8 days), cardiogenic shock, severe aortic stenosis, heart failure in the stage of decompensation, severe arterial hypotension, tachycardia, pregnancy, breastfeeding. Restrictions on use: You should refrain from using the drug in pediatric practice, since the safety and effectiveness of its use in children have not been determined.
Side effect:
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From the cardiovascular system and blood: facial flushing with a feeling of heat, palpitations, tachycardia, hypotension (up to fainting), angina-like pain, very rarely - anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura.
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From the nervous system and sensory organs: dizziness, headache, stupor, changes in visual perception, impaired sensitivity in the arms and legs.
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From the gastrointestinal tract: constipation, nausea, diarrhea, gingival hyperplasia (with long-term treatment), increased activity of liver transaminases.
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From the respiratory system: bronchospasm.
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From the musculoskeletal system: myalgia, tremor.
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Allergic reactions: itching, urticaria, exanthema, exfoliative dermatitis.
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Other: swelling and redness of the arms and legs, photodermatitis, hyperglycemia, gynecomastia in elderly patients, burning sensation at the injection site during intravenous administration.
Interaction:
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Enhance the hypotensive effect: nitrates, diuretics, beta-blockers, tricyclic antidepressants, fentanyl, alcohol.
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Increases the activity of theophylline, reduces the renal clearance of digoxin.
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Increases the side effects of vincristine (reduces excretion).
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Increases the bioavailability of cephalosporins (cefixime).
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Cimetidine and ranitidine increase plasma levels.
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Diltiazem slows metabolism (requires a reduction in the dose of nifedipine).
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Incompatible with rifampicin (accelerates biotransformation and does not allow creating effective concentrations).
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Grapefruit juice (large quantities) increases bioavailability.
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Increases the concentration of cardiac glycosides in the blood.
Overdose:
Symptoms: severe bradycardia, bradyarrhythmia, arterial hypotension, in severe cases - collapse, conduction slowdown. When taking a large number of retard tablets, signs of intoxication appear no earlier than after 3-4 hours and can be further expressed.
Special instructions:
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Elderly patients are advised to reduce the daily dose (decreased metabolism).
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Use with caution while working for vehicle drivers and people whose profession involves increased concentration of attention.
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The drug should be discontinued gradually.
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In patients with stable angina at the beginning of treatment, a paradoxical increase in anginal pain may occur, with severe coronary sclerosis