Argininosuccinate

Argininosuccinate (AS) is an intermediate in the synthesis of urea. It consists of aspartic acid (ASP) and citrulline residues. This enzyme is necessary for the breakdown of urea and energy production. However, if there are congenital defects in the enzyme, argininosuccinate deficiency may occur. This can lead to various diseases such as kidney failure, liver failure and others.

Various methods are used to treat such diseases, including the use of argininosuccinate in the form of injections or tablets. This allows you to increase the level of argininosuccinate and improve the functioning of the enzyme. Drugs are also used that increase the level of arginine in the body, which can also help treat diseases.

However, we should not forget that each person is unique and his body may respond to treatment differently. Therefore, before starting treatment, it is necessary to consult a doctor and conduct the necessary research.

Argininosuccinate: Intermediate in urea synthesis and role in metabolism

Argininosuccinate is one of the intermediate products of urea synthesis in the human body. It is composed of aspartic acid (Asp) and citrulline (Cit) residues, forming L-argininosuccinic acid (cit-Asp). Argininosuccinate plays an important role in amino acid metabolism and is a key factor for the production of urea.

In the human body, argininosuccinate is synthesized from arginine and succinate in the liver with the participation of the enzymes arginase and succinate dehydrogenase. This process is necessary to maintain the level of urea in the blood, which is then eliminated from the body through the kidneys.

However, some people may have a congenital deficiency of the enzyme arginase, which leads to decreased synthesis of argininosuccinate. In such cases, urea levels may be elevated, which can cause various symptoms such as fatigue, nausea and vomiting.

In addition, argininosuccinate is also involved in other metabolic processes such as protein synthesis, regulation of glucose and fatty acid levels, and regulation of cellular growth and development.

Thus, argininosuccinate is an important intermediate in the synthesis of urea and plays a key role in the regulation of many metabolic processes in the body. However, its deficiency can lead to serious consequences, so it is important to monitor urea levels in people with congenital arginase enzyme deficiency.