Australian Antigen

Australia Antigen is one of the names of the hepatitis B antigen, a virus that causes acute and chronic inflammation of the liver in humans. The name "Australian Antigen" was given to this antigen due to the fact that it was first discovered in the blood of Australian Aborigines in the 1960s.

Researchers have found that the Australian antigen is a specific marker of hepatitis B and that its presence in the blood may indicate the presence of this virus in the body. Moreover, scientists noted that the presence of the Australian antigen in a patient may be associated with a more severe course of the disease and a high likelihood of developing chronic hepatitis.

Australian antigen is a protein that is produced inside cells infected with the hepatitis B virus. It can be detected in a patient's blood using special tests such as an enzyme-linked immunosorbent assay (ELISA) or polymerase chain reaction (PCR).

However, it is worth noting that the presence of Australian antigen in the blood does not always indicate the presence of hepatitis B. Some people may have Australian antigen in their blood without signs of illness, while others may have hepatitis B but not have Australian antigen. In addition, there are other ways to diagnose hepatitis B, such as viral load testing and antibody testing.

Despite the fact that the Australian antigen was discovered more than half a century ago, it still remains an important tool for diagnosing hepatitis B. Thanks to it, doctors can promptly detect the presence of the virus and take measures to treat and prevent complications.



**Australian antigen** is a type of HBV surface antigen (HBsAg) that can be found in Aboriginal Australians. Previously, Australian antigen was also called "Australian serum antigen" or "Australian origin antigen".

In the early years of hepatitis B (HB) research, researchers found that Indigenous Australians had elevated levels of HBsAg in their blood. This discovery has led to speculation that Aboriginal Australians may have natural protection against hepatitis B when exposed to infected people from other countries.

However, studies have shown that HBsAg is not the primary factor protecting Aboriginal Australians from hepatitis B. In fact, Australians demonstrate a significant incidence of HBV infection and incidence of hepatitis B disease within the Australian population. Like other Aboriginal people around the world, Australian people generally have high rates of hepatitis B infection within their populations. However, it is suspected that in the past, many Australian Aboriginal groups had some genomic mutation associated with Australian HBV. This protection against HBV could stem from their complex relationships with ecosystems, including animals and infections that might otherwise lead to infection.



Australia is the only country in the world where melasma is dominant. Living in the tropics leads to suppression of measles by 20-40%, and in comparison with the average norm in Russia, the incidence of measles in Australia is 19 times higher. Malaria in children is detected in three typical forms, but more often in an erased form. In children's groups it is also noted as sporadic malaria. Adolescence and primary school are characterized by mixed and erased malaria, as well as sporadic fever and macroviruses. Kidney and bladder stones are detected mainly in adults. Hemochromato



The Australian antigen, or Australia antigen, is another form of the hepatitis B gene that has been identified among the Aboriginal First Nations peoples of Australia. It all started in 1974, when scientists from the Australian National University noticed that some Aboriginal Australians were resistant to the hepatitis B virus. They attributed this feature to the presence of a resistant antigen called Australian antigen.

This antigen is part of the main hepatovirus, hepatitis B, and is an important factor in the body's defense against its infection. However, in people who do not have this antigen in their blood, the virus can develop and cause serious illness.

The Australian antigen was first discovered among the indigenous people of Australia, the Bushmen. Since then, it has been proven that the Australian antigen is also found in the Esperanto Indians and residents of other African countries, as well as in the Indians of California and Alaska. It has also been found in Asians and Africans.

The study found that the presence of the Australian antigen is associated with protection against hepatitis B in Aboriginal peoples of Australia, including tribes that had little exposure to hepatitis B epidemics before European contact. This antigen is also found in many animals, including monkeys, pigs, wolves and donkey, indicating that it may be congenital or inherited.

Features of the antigenic profile of the Australian hepatovirus genome demonstrate its strong and nonspecific immunity against hepatitis B among the aboriginal culture of Australia and the adjacent Pacific Islands. Another scenario being explored is that this antigenic gene was acquired from ancestors through genetic drift, or rather transmitted through the migration of a genetically diverse individual (Australian Aboriginal tribes) to the region. It may have been transmitted through cultural and tribal contacts in which Aboriginal people came into contact with people in northern and eastern Asia, Eastern Europe and South Asia. Therefore, the immunological protection of the Australian genotype was more likely the result of a process of long-term adaptation and acculturation than simple imprinting of certain contacts or contact of the ancestral human population with hepatitis B virus.

What is associated with the antigenic profile of Australian hepatitis remains unclear. We conducted research on the genomic part of studying the antigenic profiles of both ethnic