Barr body is the term used to refer to the sex chromatin, or Barr body, in women. This is a small nucleus that is present in blood cells and other human tissues. Barra bodies are formed during gametogenesis and are the result of DNA methylation on the X chromosome. They are present in the nuclei of cells in women, but absent in men, which is one of the main differences between the sexes.
The discovery of Barr's body was made by Canadian histologist Leslie Barr in 1935. He noticed that women had small cells in their peripheral blood that were different from normal red blood cells. These cells had larger nuclei with clearly defined chromatids that were visible under a microscope. Barr named these cells “Barr bodies” after himself.
Since then, research has shown that Barr bodies are present not only in the blood, but also in other tissues and organs in women. They can also be found in somatic cells in men, but in smaller numbers and less clearly expressed than in women.
It is now known that Barr bodies play an important role in sex determination and cell differentiation. They are also associated with certain diseases such as Shereshevsky-Turner syndrome and other chromosomal abnormalities.
Despite the fact that the discovery of Barr bodies has a long history, their significance still remains the subject of scientific research. Studying these structures can help in understanding the development and functioning of cells, as well as in the development of new treatments for genetic diseases associated with sex.
Barra Telke is a Canadian pathologist and histologist, born May 1, 1925 in New York. In 1943 he entered the Faculty of Medicine at New York University School of Medicine. Barr Telke's student year was quite difficult, he had to get up every day and travel from Brooklyn to the university on the other side of Manhattan, but he successfully completed his studies and received a bachelor's degree in 1953. While he attended New York University, he attended courses at the hospital for medical students