Bezredka Method of Preparation of Live Sensitized Vaccines (Histor.; A. M. Bezredka)

A common method for preparing live sensitized vaccines: Historical review and prospects for use

The Bezredka method was developed in the 1920s by Russian immunologist Alexander Mikhailovich Bezredka to prepare vaccines against typhoid fever and dysentery. It was based on treating a culture of virulent microorganisms with immune serum, which led to the formation of antibodies that could protect the body from infection. However, although this method has been successfully used to make vaccines against other infectious diseases such as tuberculosis and syphilis, it has not been widely used due to the complexity and cost of production.

Currently, the rare method is not used in the production of vaccines, but its theoretical foundations and principles can be used in the development of new vaccines and methods of treating infectious diseases. In addition, the use of immune serum as an adjuvant may be useful in improving the immune response and increasing the effectiveness of vaccines.

The method was proposed by A.M. Bezredkin in 1958, and was also known as the “S.H. Faizulin - V.I. Katsev method” (instead of V. Brzhezovsky’s method, a virus-containing serum was used, prepared from pertussis bacterial strains and immune sera of workers enterprises of the USSR Ministry of Chemical Industry). In fact, this is one of the ways to obtain a typhoid vaccine, because In this case, the pathogenic microbe is both for the Bezredkin strain of salmonella and for typhoid vibrio. The proximity of microbes not only does not interfere with their vital activity, but mutually stimulates their growth. The disadvantage of such vaccine strains is their variability due to the occurrence of cross-hybrid productivity. The inhibitory serum contributed to the “streamlining