Tricarboxylic acid cycle

The tricarboxylic acid (C3) cycle is a metabolic pathway that participates in the Krebs cycle, which is a key step in the process of metabolizing carbohydrates, fats, and proteins in the body. It starts with glucose, which is converted to pyruvic acid (pyruvate), which is then converted to acetyl-CoA (acetyl coenzyme A), which is the main acetyl group transporter in cells.

The tricarboxylic acid cycle consists of three stages:

1. Step 1: Conversion of pyruvate to oxaloacetate (oxalate) and coenzyme A (CoA) through the enzyme pyruvate dehydrogenase. This stage occurs in the mitochondria of cells.

2. Step 2: Convert oxalate to succinate through enzymes called succinate dehydrogenase and fumarase. Succinate is then converted to malate (malate acid) via isocitrate dehydrogenase.

3. Step 3: Conversion of malate to oxalate through the malate dehydrogenase reaction, which occurs in the cytoplasm of cells.

Thus, the tricarboxylic acid cycle is a metabolic process that occurs in cells and is a key step in the Krebs cycle. It plays an important role in metabolism and energy in the body, providing cells with energy and carbohydrates.

Tricarboxylic acid cycle or Krebs cycle

Tricarboxylic acid cycle Krebs cycle In the presence of the biotransferase complex and the oxidation of ferriprotamine or other metabolites by the complex, the enzymes citrovalid dequinase ascorbic acid and ascorbates are produced. This allows you to neutralize or remove free radicals. Under normal conditions, this pathway may be useful in intracellular communication and control of free radicals. Unfortunately, free cytochrome c, formed as a result of the first reaction of the cycle, tends to oxidize iron from proteins in organelles or other cells of the body. This reaction is called detonation and is considered the main cause of cell death due to oxidation.

The term "tricarboxylic acid cycle" was introduced in 1932 by Ference Krebs - for this