Clarissance

Country of origin - Russia, ICN Polypharm Russia, Pharmstandard-Leksredstva Russia

Pharm-Group - H1-histamine receptor blockers

Manufacturers - AI CN Leksredstva (Russia), AI CN Polypharm (Russia), Pharmstandard-Leksredstva (Russia)

International name - Loratadine

Synonyms - Alerpriv, Vero-Loratadine, Clallergin, Clargotil, Claridol, Claritin, Clarifarm, Clarifer, Clarotadine, Lomilan, Loragexal, Loratadine, Loratadine-Hemofarm, Lorid, Tirlor, Erolin

Dosage forms - syrup 1 mg/ml, tablets 10 mg

Composition - Active substance - loratadine.

Indications for use - Allergic rhinitis (seasonal and year-round), hay fever, allergic conjunctivitis, chronic idiopathic urticaria, itchy dermatoses (contact allergic dermatitis, chronic eczema), allergic reactions to insect bites, pseudoallergic reactions to histamine liberators, angioedema, bronchial asthma (auxiliary agent ).

Contraindications - Hypersensitivity, lactation, children under 2 years of age. Use during pregnancy is only possible if the expected benefit to the mother outweighs the potential risk to the fetus and newborn.

Side effects - Headache, drowsiness, fatigue, impaired concentration, dizziness, nervousness, anxiety, agitation (in children), insomnia, fainting, amnesia, depression, hyperkinesia, tremor, paresthesia, hypoesthesia, dysphonia, blurred vision, changes in lacrimation, conjunctivitis, blepharospasm, pain in the eyes and ears, tinnitus; dry mouth, increased appetite, weight gain, anorexia, nausea, changes in salivation, taste disturbance, toothache, stomatitis, vomiting, gastritis, flatulence, dyspepsia, constipation or diarrhea; very rarely - jaundice, hepatitis, liver necrosis; nasal congestion, sneezing, dry nose, nosebleeds, sinusitis, pharyngitis, laryngitis, cough, hemoptysis, bronchitis, bronchospasm, chest pain, upper respiratory tract infections, dyspnea; change in urine color, painful urge to urinate, dysmenorrhea, menorrhagia, vaginitis, decreased libido, impotence, edema; back pain, arthralgia, myalgia, calf muscle cramps; hyperemia, skin rash, urticaria, dermatitis, itching, angioedema, very rarely - anaphylaxis; hypertension or hypotension, palpitations, tachycardia, supraventricular tachyarrhythmia; dry hair and skin, thirst, asthenia, malaise, fever, chills, photosensitivity, increased sweating, pain in the mammary glands, weight gain, very rarely - alopecia, enlarged chest, erythema multiforme.

Interaction - Erythromycin and ketoconazole, cimetidine increase the concentration of loratadine and its active metabolite in the blood. Reduces plasma levels of erythromycin.

Overdose - Symptoms: headache, drowsiness, tachycardia. Treatment: induction of vomiting with ipecac syrup, gastric lavage, administration of activated charcoal; symptomatic and supportive therapy.

Special instructions - It is recommended to discontinue treatment at least 1 week before performing a skin test for allergens.

Literature:

1. Instructions for use of the drug "Clarisens Syrup" were approved by the Pharmacological Committee of the Ministry of Health of the Russian Federation on June 14, 2001.
2. Instructions for use of the drug "Clarisens tablets" were approved by the Pharmacological Committee of the Ministry of Health of the Russian Federation on June 14, 2001.
3. Encyclopedia of drugs