Duellin

Country of origin - Hungary
Pharm-Group - Antiparkinsonian dopaminergic drugs

Manufacturers - Egis pharmaceutical plant (Hungary)
International name - Levodopa + Carbidopa
Synonyms - Dopar 275, Zymox, Izikom, Izikom mite, Carbidopa and Levodopa - Teva, Carbidopa/Levodopa, Levodopa+carbidopa, Nakom, Sindopa, Sindopa 110, Sindopa 275, Sinemet, Sinemet SR, Tidomet LS, Tidomet plus, Tidomet forte, Tremonorm
Dosage forms - tablets 10mg/100mg, tablets 25mg/100mg, tablets 25mg/250mg
Composition - Active substance - Levodopa + Carbidopa
Indications for use - Parkinson's disease, symptomatic parkinsonism
Contraindications - Severe atherosclerosis, hypertension, liver, kidney, blood diseases, glaucoma, melanoma, bronchial asthma, mental illness, uncompensated pathology of the cardiovascular, respiratory, endocrine systems.
Side effects - Choreoathetoid hyperkinesis, arrhythmias, psychotic and paranoid reactions, dyspepsia, dizziness, visual impairment, hemolytic anemia, agranulocytosis, leukopenia, alopecia, allergic reactions, ulceration of the gastrointestinal tract.
Interaction - The effect weakens vitamin B6. Enhances the effect of MAO inhibitors.
Overdose - Symptoms: muscle twitching, convulsive closing of the eyelid, nausea, vomiting, diarrhea, irregular and rapid pulse, loss of consciousness, convulsions, anxious agitation, hallucinations, coma. Treatment: Call an ambulance immediately. If the patient is unconscious, he should be placed on his side to prevent aspiration of vomit.
Special instructions - Limits use: pregnancy, children under 12 years of age, history of myocardial infarction. During treatment, nursing mothers should stop breastfeeding. During treatment, it is necessary to periodically conduct blood tests, check liver and kidney function.
Literature - Encyclopedia of Medicines 2002, Mashkovsky M.D. No13, Kharkevich "Pharmacology" p. 205., Griffith "Medicines" vol. 1, p. 705