Фосфокреатин (Phosphocreatine)

Phosphocreatine is one of the most important components of muscle tissue and plays a key role in cellular energy metabolism. It is an organic acid found in muscles and other tissues of the body.

Phosphocreatine is formed by a reaction between creatine and phosphokinase, which catalyzes the conversion of creatine to phosphocreatine. In muscles, phosphocreatine plays the role of a reserve source of energy, which is used to maintain muscle activity when there is a lack of oxygen and nutrients.

During physical activity, phosphocreatine is quickly consumed, which leads to a decrease in creatine levels in muscles. However, thanks to the rapid synthesis of creatine from phosphocreatine, muscles are able to quickly restore creatine reserves and maintain their activity at a high level.

A lack of phosphocreatine can lead to decreased muscle strength and endurance, as well as disruption of the heart and other organs. Therefore, it is important to maintain optimal levels of phosphocreatine in the body, which is achieved through proper nutrition and regular exercise.

In addition, phosphocreatine can be used as a medicine to treat various diseases such as diabetes, cardiovascular disease and muscle injuries. In this case, it is introduced into the body in the form of injections or tablets.

Thus, phosphocreatine is an important component of cellular energy metabolism and plays an important role in maintaining the health of the body. Its deficiency can lead to various diseases, so it is important to monitor its levels and maintain them at an optimal level.

Phosphoric creatine compounds are high-energy phosphorylated derivatives of an amidated nitrogen-containing heterocyclic (pyrazolyl) intermediate formed from phosphoenolpyruvate. This intermediate is a precursor to a large number of metabolites that are involved in cellular energy supply. Of the various phosphorus creatine compounds, the most widely used are phosphocreatine and its semicarbazide derivative - creatitediamide, which is (7-aminomethoxy-2-(3-phosphate) ethane-1,2-dicarboxylate.

Phosphorus in creatine can be expressed in one summary equivalent by a general structural formula: it is a dicarboxamide tetriode, formed by the condensation of phosphoenolapirovanant and creatic acid (IUPAC name):

In the homocitrate dehydrogenase reaction, glyceraldehyde-3-phosphate (often also called 3-phosphoglycerate) is hydrolyzed to the glyoxylate cycle using NAD+ and CO2. The 4th carbon atom in pyruvate-4-carboxylase fixes CO2 in pyronic acid to form oxaloglutarate.