Hyperindicanemia

Hyperindicanemia: understanding and consequences

Hyperindicanemia, also known as hyperindolemia or indicanemia, is a condition in which the level of indican in the blood is elevated. Indican is a metabolite of tryptophan, an amino acid that plays an important role in the formation of serotonin. Elevated indican levels may indicate problems with the digestive system or other diseases.

Hyperindicanemia can occur due to several reasons. One of them is a decrease in the activity of enzymes responsible for processing tryptophan in the intestines. This may be due to problems with the digestive system, such as irritable bowel syndrome or inflammatory bowel disease. Hyperindicanemia may also be associated with a disturbance in the intestinal microbiota, when the normal balance between beneficial and harmful bacteria is disrupted.

Elevated indican levels can have negative effects on the body. Indican can be converted to indole and other toxic compounds in the intestines, which are then absorbed into the blood. These toxins can negatively affect the functioning of various organs, including the liver and kidneys. Hyperindicanaemia may also be associated with the development of symptoms such as chronic fatigue, headaches, digestive disorders and mood disorders.

Diagnosis of hyperindicanemia involves testing the level of indican in the blood or urine. If the level of indican exceeds the norm, then further examination is carried out to identify the reasons for the increased value. This may include examination of the digestive system, analysis of gut microbiota, and investigation of other associated symptoms.

Treatment of hyperindicanemia is aimed at eliminating the underlying disease or restoring the normal balance of the intestinal microbiota. This may include dietary changes, taking probiotics or medications to help normalize the digestive process. In some cases, medications or surgery may be required.

In conclusion, hyperindicanemia is a condition in which the level of indican in the blood is elevated. This may be due to disturbances in the digestive system or an imbalance of the intestinal microbiota. Elevated indican levels can have negative effects on the body and require diagnosis and treatment. Early recognition and management of hyperindicanemia can help restore digestive health and reduce the risk of developing associated symptoms. If you suspect hyperindicanemia, it is recommended to consult a doctor for diagnosis and development of an individual treatment plan.

Hyperindication (synonyms indekianamma, hyperindication, etc.), literally (hyper- + indicanemia), “increased urobilin levels” is the presence in the blood of an increased amount of inactive hemoglobin metabolites not bound to proteins, such as uroerythrol, uroporphyrin or urobilinogen. These hemoglobin breakdown products appear under various physiological and pathological conditions. Normally, the release of urobilin bodies is 12-20 mg; with chronic hemolysis, their content in the patient’s body increases in