Adrenocorticotrophic Hormone, Adrenocorticotrophin

Adrenocorticotropic hormone (ACTH) is a hormone of the anterior pituitary gland that stimulates the adrenal cortex to produce glucocorticoid hormones. ACTH plays a key role in regulating homeostasis and the body's response to stress.

Main functions of ACTH:

1. Stimulation of the synthesis and secretion of glucocorticoids (cortisol) in the adrenal cortex. This is the main mechanism of action of ACTH.

2. Regulation of metabolism. ACTH indirectly affects carbohydrate, protein and fat metabolism through glucocorticoids.

3. Effect on immunity. ACTH has an immunosuppressive effect.

4. Involvement in the stress response. During stress, ACTH production increases sharply, which leads to the release of glucocorticoids and the body's adaptive response.

5. Regulation of pigment metabolism. ACTH stimulates melanin synthesis.

Thus, ACTH plays an important role in the regulation of many processes in the human body. Disturbances in the ACTH system lead to the development of serious endocrine diseases.

Adrenocorticotropic hormone (Adrenocorticotropic Hormone), Adrenocorticotropin (Adrenocort icotropin, abbr.: ACT H or ACT G) is a peptide hormone of the anterior pituitary gland that controls the function of the adrenal glands. The formation of ACTH occurs mainly in the intermediary nucleus of the hypothalamus, from where it is released along the axons by neurons innervating the adenohypophysis. Adrenosine ACTH activates the distal pituitary gland and causes the production of ACTH2 in large granules that are located in the anterior pituitary gland. It connects the Hindreich pathway to activate steroidogenesis. Zona fasciculata cells use the ASIP protein to stimulate the secretion of ACTX. When the anterior lobe of the pituitary gland is destroyed, a basal level of axrenin is formed. After this, the ACTX peak falls in the 3rd week (levels decrease by approximately 40%, although the exact dynamics are not clear). ACTH can be stimulated by large doses of glucocorticoids, in turn caused by stimulation of amyloid beta or adrenaline. If neutralized through the desensitizing effect of Cortava, it will likely be reduced to physiological levels.