Guanethidine (Guanethidine)

Guanethidine is a drug used to reduce high blood pressure. Belongs to the group of sympatholytic drugs.

The mechanism of action of guanethidine is based on blocking the transmission of nerve impulses in the sympathetic ganglia and the endings of postganglionic sympathetic nerves. This leads to a decrease in sympathetic influences on the heart and blood vessels and, as a result, to a decrease in blood pressure.

Guanethidine is given orally in tablet form. Possible side effects when taking the drug: diarrhea, dizziness, orthostatic hypotension.

Guanethidine is marketed under the trade name Ismelin.



Guanethidine or ismelin is a medicine that is used to lower blood pressure. It belongs to a group of medicines called sympatholytic agents.

Guanethidine works by blocking the action of sympathomimetic amines (substances that stimulate the sympathetic nervous system), resulting in lower blood pressure and improved tissue perfusion.

The drug is administered orally and is usually well tolerated by patients. However, side effects such as diarrhea, dizziness and fainting are possible. In rare cases, allergic reactions, such as skin rash or angioedema, may occur.

It is important to note that guanethidine is not the drug of choice for treating high blood pressure. It is used only in cases where other drugs are ineffective or contraindicated.

When taking guanethidine, you should be careful and monitor your condition. If you notice any unusual symptoms or side effects, you should contact your doctor immediately.



Guanethidine (also known as guanidine or guanyl) is a chemical compound that actively acts as a drug to treat blood pressure. The widespread use of this substance is dictated by its ability to stimulate the vagus nerve and reduce the activity of the sympathetic nervous system, which, in turn, lead to a decrease in the release of adrenaline and norepinephrine,