**Hemoglobinuria** is a rare pathological condition that occurs as a result of the synthesis of a pathological form of human hemoglobin. In particular, this disease may be associated with mutations in MHC genes. In patients with hemolytic anemia with one normal hemoglobin, an alternative hemoglobin is synthesized, which is called hemoglobin nephrogen, as well as Saint-Girons hemoglobinia or indirect Aschard hemoglobinuria. In addition, the hemoglobinuria phenotype also occurs in some fish species such as salmon, seal and sardines. No other mechanism for the occurrence of hemoglobinemia was currently known, but researchers