Hill Method

Hill's method is a method for obtaining haploid cells of the yeast Saccharomyces cerevisiae by using factors of the mitotic apparatus that can increase the lag in the mitotic rate curve and lead to the arrest of cell division in metaphase. It was discovered by Arthur Williams Hill in 1957 and has its theoretical basis in the bioenergetic theory of living organisms by Maurice Kihara.

Hill's discovery was made while studying the process of photosynthesis and the excitation response, which was associated with changes in the rate of mitosis of cells containing photosynthetic pigment. In 1942, physiologist William Davison, who noticed during experiments that yeast cells were arrested at the metaphase stage, used histochemical methods to show that the cells contained