Hyperinsulinism

Hyperinsulinism is a pathological condition characterized by increased secretion of insulin.

Causes of hyperinsulinism:

1. Excessive production of insulin by pancreatic β-cells. This may be due to pancreatic tumors, genetic mutations or idiopathic factors.

2. Excessive administration of insulin in the treatment of diabetes mellitus. Excessive doses of insulin can cause hypoglycemia and other complications.

Clinical manifestations of hyperinsulinism: hypoglycemia, convulsions, dizziness, loss of consciousness. Chronic hyperinsulinism can lead to obesity and decreased tissue sensitivity to insulin.

Diagnosis is based on determining the level of insulin and glucose on an empty stomach and after meals. Treatment depends on the cause and includes diet, medication, and in some cases surgery. Controlling glucose and insulin levels is important to prevent complications.

Hyperinsulinism (HIP) is a condition in which the pancreas produces increased levels of insulin without adequate contraction of islet cells. This leads to the development of many diseases and health problems. In this article, we will discuss the symptoms and treatment of HIP.

Hyperinsulism can be caused by a variety of factors, including genetics, poor diet, infections, or certain medications. However, the most common cause is type 1 diabetes, where the pancreas does not produce enough insulin to control blood glucose levels. In people with diabetes, insulin levels may be elevated, causing HIP symptoms. When insulin levels are elevated, symptoms such as swelling, extreme fatigue, excess appetite, weight gain, and skin problems may develop. You may also experience excessive hunger, drowsiness, and a feeling of constant thirst. In more serious cases, a person may experience weight loss, decreased body size, decreased energy levels, and seizures.

Hyperinsulism is a pathological condition that occurs due to excessive secretion of insulin by the cells of the islets of Langerhans, tissue hypersensitivity to the action of insulin, or cessation of secretion of insulin antibodies. General symptoms may include hyperinsulinemia, hypoglycemia with glycemic decompensation, including the appearance of neurological symptoms and polyuria. Diagnosis is made by measuring fasting serum insulin levels, oral glucose tolerance tests, insulin/glucose ratios, and pancreatic insulin production, as well as PET scans with insulin and

Hyperinsulinemia is a condition characterized by excessive production of insulin in the cells of the pancreatic islets, which leads to impaired carbohydrate metabolism. This condition develops due to an increase in tissue sensitivity to insulin compared to its normal content in the body. In addition, excess insulin may be associated with disruption of other endocrine glands, such as the pituitary gland and adrenal glands. This leads to an increased risk of developing diabetes, obesity, hypertension and other diseases.

The reasons for increased insulin levels may be: - Pancreatic cancer; - Tumors of the gastrointestinal tract (stomach, liver, intestines); - Liver diseases; - Obesity.

With hyperinsulinemia, the insulin level exceeds the norm, which is 3-5 mmol/l. If this does not happen, then we can talk about insulin deficiency.

The first signs of the disease:

- Weight loss; - Tachycardia (rapid heartbeat); - Increased sweating; - Increased appetite; - Fast fatiguability;

A hyperinsulinemic state leads to metabolic disorders, including glucose metabolism, which can lead to the development of diabetes mellitus or its worsening. At the same time, the pancreas begins to produce even more insulin to maintain normal blood glucose levels. This can lead to depletion and atrophy of insulin-producing cells. There may also be a decrease in fructose synthesis and an increase in sorbitol secretion, which aggravates the disease.

Prevention and treatment: