Interepithelial Space

Interepithelial space (lat. spatium interepiteliale) is a small amount of free space located between the slit-like terminal ducts of the gland and overlying the surface epithelial layer in the tissues and organs of many animals and humans.

Interepithelial spaces are formed due to uneven deposition of secretions in the alveoli of the exocrine glands. In pathologies of the gastrointestinal tract, they are important in the occurrence of mesenchymal effusions into the abdominal cavity. The formation of free interepithelial fluid also occurs during inflammation of the laminated and glandular organs - the biliary tract and bladder. Most often, information about interepithelial spaces is found in the medical field when describing a disease such as pancreatitis. If the interstitial fluid in the pancreas is not diagnosed or treated in a timely manner, many complications arise that significantly complicate the patient’s life. Most often, in addition to general intoxication manifestations, a person complains of pain in the abdominal area, especially in the right hypochondrium. This is due to a direct increase in gland tissue, as well as displacement of the diaphragm due to the accumulation of fluid. This kind of pain is severe and excruciating, and it always occurs suddenly. Treatment requires immediate medical intervention.