Major Histocompatibility Complex (Mhc)

The Major Histocompatibility Complex (Mhc) is a series of genes located on chromosome No. 6 that encode certain antigens, including HLA antigens. These genes play an important role in the process of determining histocompatibility in humans.

The Mhc complex consists of many closely linked genes that encode proteins that present antigens on the surface of cells. These proteins allow the immune system to distinguish the body's own cells from foreign ones. Mhc genes fall into three main classes.

Class I genes encode HLA molecules present on the surface of all nucleated cells. They present intracellular peptides to CD8+ T cells, triggering an immune response against viruses and other intracellular pathogens.

Class II genes encode the HLA-DR, HLA-DP, and HLA-DQ molecules expressed by antigen-presenting cells. They present peptides derived from external antigens to CD4+ T helper cells.

Class III genes encode various immune regulatory proteins such as complement components and cytokines.

Thus, the major histocompatibility complex plays a key role in recognizing foreign antigens and triggering the immune response. Mhc gene polymorphism provides diversity in the immune repertoire in a population.

The Major Histocompatibility Complex is a series of genes that are located on chromosome 6 and encode HLA-type antigens. These antigens play an important role in determining the compatibility of human body tissues and are an important factor in organ and tissue transplantation.

The histocompatibility complex is made up of several genes that are found on chromosome 6. One of them is HLA-A, which encodes the A antigen. This antigen is one of the most common HLA antigens and plays an important role in the body's immune response.

Another gene, HLA-B, also encodes the B antigen, which is the second most common HLA antigen. The HLA-C, HLA-D and HLA-E genes also encode important histocompatibility complex antigens.

The genes encoding HLA complex antigens are located on human chromosome 6 and play an important role in the body's immune system. They determine tissue compatibility during organ transplantation, and also participate in the formation of the immune response to various infections and diseases.

Additionally, research shows that HLA complex genes may be associated with various diseases such as cancer, autoimmune diseases and others. Therefore, the study of the HLA complex and its role in the human body is an important area of ​​research in the field of immunology and medicine.

The Major Histocompatibility Complex (MHC) is a complex genetic mechanism that regulates the interactions between cells, tissues and the body's immune system. It plays a major role in determining the individual compatibility of cells and tissues, which in turn allows the body to effectively fight infection and maintain health. The MHC complex is made up of many different elements, ranging from proteins to specific markers, but it is best known for the presence of the HLA group of genes that are responsible for displaying antigens. These antigens are important components of the MHC complex and help the immune system identify antigenic cells that can cause a reaction.

What is HLA? The MHC antigen genes, known as HLA (Human Leucocyte Antigens), are located on the short arm of chromosome 6. How does it work? MHC coding of genes is related to the immune system. Mutations in these genes can cause immune system dysfunction and various health problems. When the body encounters an infection, its immune system is able to recognize foreign proteins as hostile elements and activate its defense functions. The preparatory and activating phases of the immune system response are controlled by HLA genes. An important step here is signaling proteins such as TNF-α. Such molecules are rapidly transported to sites of activation of immune cells, such as lymphocytes. All this describes the so-called concept of “Hypersensitivity”