Leucovorin Calcium

Leucovorin calcium: description, use, contraindications and side effects

Leucovorin calcium (calcium folinate) is a pharmacological agent from the folic acid group, used in medicine for the treatment of methotrexate intoxication, megaloblastic anemia of iatrogenic origin and folinic hypo- and vitamin deficiency.

The country of origin of leucovorin calcium is the United States of America. Manufacturers - Vaeth-Lederle (USA).

Leucovorin calcium is available in a variety of dosage forms, including lyophilized powder for injection 50mg, 100mg and 350mg, injection 3mg/ml and tablets. The active substance is calcium folinate.

Indications for the use of leucovorin calcium include the treatment and prevention of methotrexate intoxication, megaloblastic anemia of iatrogenic origin, as well as folinium hypo- and vitamin deficiency.

Despite its effectiveness, there are contraindications to the use of leucovorin calcium. Hypersensitivity to this drug, pernicious and other megaloblastic anemia due to vitamin B12 deficiency are contraindications to its use. In addition, during pregnancy and breastfeeding, the medicine can be used only in absolutely necessary cases.

Side effects of leucovorin calcium include allergic reactions. Interaction with other drugs may lead to a weakening of the effect of methotrexate, including the therapeutic effect.

There is no evidence of an overdose of leucovorin calcium. However, calcium folinate solution for infusion should be prepared ex tempore and can only be used within 12 hours.

In conclusion, leucovorin calcium is an effective pharmacological agent that is used in medicine to treat a number of diseases. However, before using it, you should consult your doctor to make sure there are no contraindications or possible side effects.