Country of origin: Russia
Pharm-Group: Antimicrobials - fluoroquinolones
Manufacturers: Veropharm/Belgorod branch (Russia)
International name: Ofloxacin
Synonyms: Glaufos, Zanotsin, Zanotsin OD, Quiroll, Meneflox, Oflin, Oflo, Ofloxacin, Ofloxacin-AKOS, Ofloxacin-Promed, Ofloxacin-FPO, Ofloxin, Ofloxin 200, Oflocsid, Oflocid forte, Tarivid, Tariferid, Taritsin, Urosin, Floxal
Dosage forms: film-coated tablets 200 mg
Composition: Active ingredient - Ofloxacin.
Indications for use: Severe infections of the respiratory tract (pneumonia, lung abscess, bronchiectasis, exacerbation of bronchitis), ENT organs (except acute tonsillitis), skin and soft tissues, bones and joints, abdominal cavity, pelvic organs, kidneys, urinary tract , genital organs (including gonorrhea, prostatitis), chlamydial infections, septicemia, bacterial corneal ulcers, conjunctivitis; complex therapy of tuberculosis, prevention of infections in patients with immunodeficiency.
Contraindications: Hypersensitivity (including to other fluoroquinolones, quinolones), epilepsy, dysfunction of the central nervous system with a decrease in the threshold of convulsive readiness (after traumatic brain injury, stroke, inflammatory processes of the central nervous system), pregnancy, breastfeeding (stop during treatment ), children and youth (up to 18 years).
Side effects: Dyspepsia, nausea, vomiting, diarrhea, anorexia, abdominal pain, dry mouth, pseudomembranous colitis; dizziness, headache, insomnia, anxiety, decreased reaction speed, agitation, increased intracranial pressure, tremors, convulsions, nightmares, hallucinations, psychosis, paresthesia, phobias, impaired coordination of movements, taste, smell, vision, diplopia, color perception disorders, loss of consciousness, transient increase in the level of bilirubin and liver enzymes in the blood plasma, cardiovascular collapse, acute interstitial nephritis, impaired renal excretory function with increased levels of urea and creatinine, hypoglycemia (in patients with diabetes), hepatitis, jaundice, vasculitis, tendinitis, myalgia , arthralgia, vaginitis, hemolytic and aplastic anemia, thrombocytopenia, including thrombocytopenic purpura, leukopenia, neutropenia, agranulocytosis, pancytopenia, dysbiosis, superinfection, photosensitivity, allergic reactions (skin rash, itching, angioedema, including laryngeal, pharyngeal, face, vocal cords, bronchospasm, urticaria, exudative erythema multiforme, Stevens-Johnson syndrome, toxic skin necrosis, anaphylactic shock). When used in ophthalmology: burning sensation and discomfort in the eyes, redness, itching and dryness of the conjunctiva, photophobia, lacrimation.
Interaction: Antacids (calcium and magnesium preparations), iron sulfate, saline laxatives, sucralfate, zinc, daedalon reduce absorption and reduce activity (the interval between doses should be at least 2 hours), probenecid, cimetidine, furosemide and methotrexate inhibit excretion and may increase toxicity. Increases the concentration of glibenclamide. Do not mix in solution with heparin (risk of precipitation).
Overdose: Symptoms: drowsiness, nausea, vomiting, dizziness, disorientation, lethargy, confusion. Treatment: gastric lavage, maintenance of vital functions.
Special instructions: After the disappearance of clinical signs, treatment is continued for 2-3 days. Prescribe with caution to patients with cerebral atherosclerosis. Constant monitoring is required when combined with insulin, caffeine, theophylline, cimetidine, cyclosporine, NSAIDs, oral ant