Leptocyte

**Leptocytes** are a type of nuclear leukocytes that act primarily as microphages and are subject to destruction in the phagocytic sieves of tissues, but sometimes release intracellularly accumulated material and become local producers. Widely distributed in tissues or serve as autophages. The number of leptocytes in blood and tissues is approximately the same, ranging from 90 to 400 or less per cubic mm or µl. The definition of leptocyte is given - “erythrocyte without a nucleus.”

Leptocytosis - an increase in the absolute number of leptocytes in peripheral blood - is observed in some acute infectious diseases, immune and inflammatory reactions, in infections of a bacterial, parasitic or fungal nature, in cases of severe blood loss, after extensive surgery, extensive burns, and other significant injuries. After eliminating the cause that caused this condition, the reverse process begins - leukopenia. Leptocytosis is a causeless condition that occurs as a result of errors in blood sampling. Under normal conditions, such errors can lead to the development of hemolytic uremic syndrome, leukopenia, and bleeding.

Examples of eosinophilic granulomas containing amyloid inclusions (basophilic or amorphous eosinophilic) typical of sarcomitoses are demonstrated in cells obtained from bone marrow. Pearlescent glow is observed not only in eosinophilic, but also in some other granulocytes. Actinolysis usually does not occur simultaneously - first, the cortical plates are destroyed along their contour, and lighter particles are formed, often with a network of thin radial filaments. At the same time, a network of small hollow bubbles appears in a state of complete absence of nuclei. Another specific picture of the myelogram smear is the so-called dissociated appearance of the cell shape (with displaced nuclei in the center), which usually occurs during periods of massive activation of leukopoiesis, an increase in the number of young blast leukemia (leukocytes) and powerful leukocytopenia (the so-called picture of acute leukemia). Both of these pictures require appropriate interpretation, especially in connection with the prescription of certain therapeutic measures. Eosinophilic surge in the form of scattered “disembarked” leukemic metaplasia