Macroautoradiography is a method for studying tissues and cells using microscopic staining of micro-areas using a microscopic method, followed by etching to identify histoarchitectural features. To obtain an image, a dried preparation containing a sufficient amount of tissue and cellular structures is taken, dried under special conditions and subjected to laboratory processing (fixation, microwave drying). The macroautoradiograph device consists of three main components: a frame through which the sample passes under electron radiation, an electron source and a radiation counter. The device uses selective electron sources with a low yield of X-ray radiation, which differs from conventional radiation in that it is well filtered by opaque structures. Radio autograph can be digital or film. The digital form of macromotion is more advanced because it allows for rapid, repeated and accurate testing of multiple drugs in a short time. Digital conversion can significantly reduce the duration of drug exposure.