Normoblast

A normoblast is a cell with a nucleus that is the immediate predecessor of a normal red blood cell. Typically these cells are present in the hematopoietic tissue of the bone marrow.

Normoblasts undergo three stages during their maturation:

1. Early stage or basophilic normoblast.

2. Intermediate stage or polychromatic normoblast.

3. Late stage or orthochromatic normoblast.

Normoblasts transform into mature red blood cells through nuclear extrusion and loss of organelles. The process of normoblast maturation is called erythropoiesis.

Normoblasts (normoblastic erythrocytes, normocytes) are bone marrow cells that are the immediate precursors of erythrocytes. They have a round shape and a core located in the center. Normoblasts represent one of the stages of development of erythroid cells.

Normoblasts can be in different stages of development:

– Basophilic normoblasts have a basophilic nucleus and basophilic cytoplasm. They are the earliest stage of development of normoblasts and are the precursors of red blood cells that do not yet have hemoglobin.
– Polychromatophilic normoblasts also have a basophilic nucleus, but their cytoplasm becomes more polychromatic (multicolored). This means that normoblasts begin to accumulate hemoglobin.
– Orthochromatic normoblasts are the last stage of development. They have a nucleus with chromatin and a cytoplasm colored red. This means they contain large amounts of hemoglobin and are ready to leave the bone marrow and enter the bloodstream.

During their development, normoblasts go through several division cycles, each of which leads to an increase in the size and amount of hemoglobin in the cell. They eventually mature and become mature red blood cells, ready to carry oxygen to the body's tissues.

Normoblasts (normocytes) are cells that are the immediate precursors of red blood cells in maturation. During maturation, the number of cells goes through three stages (states): the early stage (basilphilic), the ripening stage (intermediate) and the mature stage (orthochromatic). In general, normoblasts, like other types of primordial germ cells, must transform into sexually mature cells. To do this, they go through all known stages of differentiation with the formation of specific functional proteins that determine the direction of individual development.