Organotropy

Organotropy is the selective affinity for a specific human organ on the part of various external agents. For example, a bacterial toxin is organotropic, since it affects only certain cells of the host body - the thymus - while irreversibly destroying them (destruction of T-lymphocytes). Currently

Organotropy is the ability of microorganisms to cause disease only under certain conditions and only in the affected organ. Organotropic properties are widespread among microorganisms. It is almost always possible to isolate a pathogen (pathogen) that affects certain organs. Bacterial adhesion plays an important role in organotropy. Adhesion is the process of binding microorganisms to epithelial cells, endothelium or plasma lipoproteins for the purpose of invasion. When binding, the electrochemical gradient changes from outside to inside and the exchange of certain metabolites that are necessary for the life of cells occurs, and the cytoplasmic membrane has outgrowths - pinaconoids, opsons, bacterial components of mucus, proteins that make up biofilms, citrate ion profile (pH = 6.5 ; pH = 7). Aggregation of the pathogen occurs by increasing the number of free ribosomes through disruption of the function of the endoplasmic reticulum, supramembrane and nucleoplasmic apparatus.