Pancreas Artificial Implantable

An artificial pancreas (APG) is a medical device that simulates the functioning of the human pancreas. This device is intended to compensate for impaired insulin secretion caused by genetic or acquired diseases (for example, type 2 diabetes and insulinoma).

When a person eats food, his stomach

Intramural or artificial pancreas (artificial beta cells) is an innovative method of treating type 1 and type 2 diabetes mellitus. This is an invasive method that involves implanting an artificial gland into the wall of the stomach or duodenum, from where it will release insulin into the body.

The development of a disease associated with chronic pancreatic insufficiency leads to impaired carbohydrate metabolism and health problems in patients. The beta cells that are involved in the production of insulin are destroyed and cannot release it in sufficient quantities. The problem can be solved by implanting an artificial beta cell into the stomach or duodenum. This process requires preparation and surgery, but provides long-term benefits for patients with diabetes.

To implement the technology for producing an artificial pancreatic gland, pancreatic beta cell enzymes are used and the cells are cultured under ex vivo conditions. The resulting substance is then encapsulated inside a sphere of biodegradable polymer material, which serves as a carrier for delivery to the target area. This procedure allows the creation of artificial beta cells that have the necessary properties to replace functional defective beta cells.

Artificial beta cells are also protected from the immune system and can function for up to 4-6 months before requiring replacement. However, this period significantly exceeds the lifespan of natural beta cells, which is just over 7 days. Therefore, the prognosis regarding the long-term effect of an artificially implanted pancreatic gland is quite optimistic. Also, this method allows you to switch to maintenance insulin therapy and abandon insulin injections when it stabilizes.

Although artificial beta cells are considered a relatively new treatment, they have several limitations. One of the main drawbacks is the lack of functionality of the devices, which were not always able to maintain a stable insulin level in the patient. Other considerations include the risk of infection, possible risks of surgery, and side effects from systemic medications or artificial insulin after surgery.

One of the main benefits of using artificial beta cells is that they can provide the patient with more precise control of insulin levels in the body. These devices usually come with software that can help monitor blood glucose levels and adjust insulin doses. Doctors can monitor the condition of the artificial insulin implant and monitor its performance. If necessary, your doctor may choose an alternative therapy strategy to adjust your insulin levels as effectively as possible.