Paschen Bodies

Paschen Bodies are viral particles that were first discovered in the keratinized cells of the epidermis in patients suffering from cowpox or smallpox. These particles are named after the German physician Gustav Paschen, who first described them in 1903.

Paschen bodies are viral inclusions that are commonly found in the skin cells of smallpox patients. They can be found in the keratinized cells that form on the surface of the skin during infection with the smallpox virus. Paschen bodies have the shape of spherical or oval bodies, ranging in size from 1 to 10 microns, and consist of viral particles and cellular components.

Research has shown that Paschen bodies are highly infectious and can cause diseases associated with smallpox. They can also be used to diagnose smallpox, as their presence in dead skin cells is a reliable sign of infection.

Despite the fact that Paschen bodies were discovered more than a hundred years ago, it is still not fully understood how they are formed and how they interact with host cells. Research in this area is ongoing and hopes that in the future it will help develop effective treatments and prevention of diseases associated with smallpox.

In conclusion, Paschen bodies are an important element in understanding the mechanisms underlying smallpox. Their detection in keratinized skin cells is a reliable indicator of smallpox infection, making them a valuable tool for diagnosing this disease. Although much is still unknown about Paschen's Taurus, he hopes that further research will help reveal all the secrets of this mysterious structure.

Paschen Bodies are viral particles found in the keratinized cells of the epidermis in patients suffering from cowpox or smallpox.

These viral inclusions were first described in 1904 by German pathologist Friedrich Paschen while studying skin biopsies from smallpox patients. Paschen discovered that the cytoplasm of virus-infected cells contains characteristic eosinophilic inclusions of round or oval shape.

Since then, Paschen bodies have been considered a pathognomonic sign of smallpox and are used for its diagnosis. They are accumulations of viral particles in the cytoplasm of epidermal cells and appear in the early stages of infection. Detection of Paschen bodies in skin biopsies still remains the “gold standard” in the laboratory diagnosis of smallpox.

Paschen bodies, also known as bobulinopathy, are viral particles found in the keratinized skin cells of vaccinia and smallpox patients. Although many speculations have been made about the purpose of these formations, the reasons for their appearance have not been clearly established. This phenomenon was first described in 1882 by James Merian, an American dermatologist, who described a rash in the form of a white intradermal “incubator” on the scrotum and perineum. This observation was one of the first evidence of cowpox, since at that time there was no way to detect the presence of smallpox

Paechen bodies are a viral particle found in cowpox, smallpox and other dermatological diseases. Viruses are related in form to this disease. Most viruses are known, but natural or cowpox (camel)pox virus exists only in a cellular state in in the form of Passion's bodies. They are formed after infection with a virus. Passion's bodies are irregularly shaped granules formed by the variola virus. Cowpox is characterized by the characteristic feature of the content of lipids or fatty deposits in the nuclei of epidermal cells. The nuclei of Paschen's body cells consist of lipid granules (eleven percent by weight) and many viral particles with a diameter of about 25-40 nm surrounding them (89% of the weight). These particles carry the immune component of the virus called virion-specific antigen (VP7). Several nuclei cells also contain various epithelial and endoplasmic membranes. When observing Paschen bodies using an electron microscope, the intracellular viral part has a spherical shape with a diameter of 20-30 nm and is mixed with lipid substances and small picols with a diameter of less than 1 nm. Severe dangerous infection leads to a strong increase in nuclei. If the initial stage of infection is mild, the nucleus remains relatively normal in size. An important aspect of the pathogenesis is the progressive damage to these structures, leading to necrosis of the epithelial structures, which includes the production of the specific protein VP7 and other viral elements. Lipid granules lose their nucleus, which in turn increases antibody levels as cells are further infiltrated by macrophages. This may indicate the beginning of a stage associated with slowing infection or recovery. Together with other signs of inflammation and necrosis, these bodily changes may indicate rapid expansion of the lesions or, alternatively, a localized infection. These specific structures are also of interest for studying the pathogen