Pyrogen

Pyrogen is a substance that causes an increase in body temperature. It can be of various origins - bacterial, viral, fungal or other. Typically, when our body detects the presence of infection or inflammation, it produces pyrogens to fight it. However, in some cases, pyrogens can cause an unnecessary increase in temperature, which can lead to hyperthermia and other dangerous consequences.

Pyrogens can be divided into two categories: endogenous (internal origin) and exogenous (external origin). Endogenous pyrogens are produced by our body in response to infections and inflammatory processes. They can be of various types, including interleukin-1, interleukin-6, and tumor necrosis factor alpha (TNF-α). Exogenous pyrogens, on the other hand, enter the body from the outside, for example through food or through wounds.

Pyrogens can cause not only an increase in body temperature, but also other symptoms such as headache, nausea and vomiting. In some cases, they can lead to complications such as seizures, coma, or even death.

Pyrogenic substances can also be used in medicine. For example, the pyrogen test (injection of small doses of pyrogen) is used to diagnose infectious diseases such as sepsis. This test helps determine the presence of pyrogens in the patient's blood and assess the degree of their infectious activity.

One example of the use of pyrogens in medicine is the drug Piroxicam. It is a nonsteroidal anti-inflammatory drug that is used to reduce pain and stiffness in osteoarthritis, rheumatoid arthritis, gout, and ankylosing spondylitis. It is taken orally and may cause side effects such as dizziness, skin rashes and gastrointestinal disturbances. The drug is available on the market under the trade name Feldene.

In general, pyrogens are important substances that help our body fight infections and inflammatory processes. However, if they are used in excess or incorrectly, they can cause negative consequences. Therefore, when using pyrogenic substances in medicine, it is necessary to take appropriate precautions and control their dosage and use.

Pyrogen: Description and Application

Pyrogens are substances that cause an increase in temperature in the body. They can be of various origins and have various effects on the human body. One example of such substances is the pyrogenic drug piroxicam.

Piroxicam, also known by the trade name Feldene, belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) or simply NAIDs. It is used to reduce pain and inflammation in various joint diseases such as osteoarthritis, rheumatoid arthritis, gout and ankylosing spondylitis. Piroxicam has anti-inflammatory, analgesic (pain-relieving) and antipyretic properties.

The drug is taken orally, usually in the form of tablets or capsules. It exerts its effect by blocking the enzyme cycloxygenase, which is responsible for the synthesis of prostaglandins - substances involved in the processes of inflammation and pain. Blocking the synthesis of prostaglandins helps reduce inflammation in the joints and reduce pain.

It is important to note that the use of piroxicam may be accompanied by some side effects. Some of these include dizziness, skin rashes and gastrointestinal problems such as dyspepsia, nausea, vomiting or abdominal pain. In rare cases, more serious side effects may occur, so it is important to consult your doctor before starting to take piroxicam and strictly follow the dosage recommendations.

In conclusion, pyrogens are substances that cause an increase in temperature in the body. Piroxicam, which is one such substance, is used to reduce pain and inflammation in various joint diseases. Despite its effectiveness, you must be aware of possible side effects and follow your doctor's instructions when using it.

Pyrogenic theory of disease

*Pyrogenic theory of disease* is an approach to studying the cause of disease, which is based on the fact that the main pathological reaction of the body is inflammation. As the name suggests, the pyrogenic theory is based on the study of the cause of inflammation. Literally translated into Russian, *pyrogenic cause* means “caused by fire.” At the moment, it is considered one of the most effective for solving problems in theoretical and clinical medicine. Pyrogenic theories, whether they are based only on simple inflammation or go further, often play a prominent role in the historical development of medicine, since it represents an essential link in the theoretical basis of medical practice and empirical knowledge and