Polyarteritis Nodose

Polyarteritis nodosa: understanding, symptoms and treatment

Polyarteritis nodosa (PAN) is a rare inflammatory disease of the large and medium-sized arteries that affects multiple organs in the body. This is a chronic disease characterized by inflammation of the arterial walls and the formation of nodes (nodes) around the arteries. PAN affects the circulatory system, causing various symptoms and can lead to serious complications if not treated promptly.

Symptoms of PAN can vary depending on the organs involved in the inflammation. Common signs may be:

1. General symptoms: general weakness, weight loss, fever.
2. Skin manifestations: purpura (bruises or spots on the skin), ulcers, non-healing wounds.
3. Muscle and joint pain: pain, stiffness and a feeling of heaviness in the muscles and joints.
4. Neurological symptoms: headaches, changes in behavior, loss of sensation or weakness in the limbs.
5. Gastrointestinal problems: abdominal pain, nausea, vomiting, bloody stools.

The causes of PAN are not fully understood. However, it is believed that autoimmune and genetic factors may play a role in the development of the disease. Perhaps a compromised immune system leads to an attack on your own tissue and artery walls, causing inflammation.

The diagnosis of PAN can be difficult due to the variety of symptoms and their secrecy. Doctors perform a comprehensive examination, including a clinical examination, blood and urine tests, arterial biopsies and instrumental studies such as angiography and computed tomography (CT).

Treatment for PAN is aimed at controlling inflammation, relieving symptoms, and preventing complications. Immunosuppressants such as corticosteroids and cyclophosphamide are commonly used to reduce the activity of the immune system. Immune modulators such as rituximab can also be used to suppress inflammation. In some cases, surgery may be required to restore blood supply to the affected arteries.

Patients with PAN require long-term medical supervision and monitoring. Regular visits to the doctor and laboratory tests will help evaluate the effectiveness of treatment and identify possible polyarteritis nodosa: understanding, symptoms and treatment

Polyarteritis nodosa (PAN) is a rare inflammatory disease of the large and medium-sized arteries that affects multiple organs in the body. This is a chronic disease characterized by inflammation of the arterial walls and the formation of nodes (nodes) around the arteries. PAN affects the circulatory system, causing various symptoms and can lead to serious complications if not treated promptly.

Symptoms of PAN can vary depending on the organs involved in the inflammation. Common signs may be:

1. General symptoms: general weakness, weight loss, fever.
2. Skin manifestations: purpura (bruises or spots on the skin), ulcers, non-healing wounds.
3. Muscle and joint pain: pain, stiffness and a feeling of heaviness in the muscles and joints.
4. Neurological symptoms: headaches, changes in behavior, loss of sensation or weakness in the limbs.
5. Gastrointestinal problems: abdominal pain, nausea, vomiting, bloody stools.

The causes of PAN are not fully understood. However, it is believed that autoimmune and genetic factors may play a role in the development of the disease. Perhaps a compromised immune system leads to an attack on your own tissue and artery walls, causing inflammation.

The diagnosis of PAN can be difficult due to the variety of symptoms and their secrecy. Doctors perform a comprehensive examination, including a clinical examination, blood and urine tests, arterial biopsies and instrumental studies such as angiography and computed tomography (CT).

Treatment for PAN is aimed at controlling inflammation, relieving symptoms, and preventing complications. Immunosuppressants such as corticosteroids and cyclophosphamide are commonly used to reduce the activity of the immune system. Immune modulators such as rituximab can also be used to suppress inflammation. In some cases, surgery may be required to restore blood supply to the affected arteries.

Patients with PAN require long-term medical supervision and monitoring. Regular visits to the doctor and laboratory tests will help evaluate the effectiveness of treatment and identify possible complications.

Polyarteritis is an autoimmune disease that manifests itself as damage to large blood vessels. In some cases (approximately 40% of cases) the disease has the character of a chronic infectious disease of unknown origin. It is also called nasal arteritis. The symptoms of the disease are similar to pulmonary arterial sclerosis. This disease poses the greatest danger during the period when its progression and rejection of small vessels continues. It can cause disruptions in the functioning of critical systems, from the heart to the stomach, and blurred vision.