Postsynaptic Potential Excitatory

Excitatory postsynaptic potential (EPSP) is a change in the membrane potential of the postsynaptic cell towards depolarization (approaching the excitation threshold) in response to the release of an excitatory transmitter from the presynaptic terminal.

EPSP occurs when ion channels are activated, allowing positively charged ions (for example, Na+ ions) to enter the cell. This leads to local depolarization of the membrane and a decrease in membrane potential. The amplitude of the EPSP depends on the amount of transmitter released and the density of postsynaptic receptors.

EPSP plays a key role in the excitation of neurons and the transmission of nerve impulses. Summation of EPSPs in space and time can lead to the generation of an action potential in the postsynaptic cell. Thus, EPSP is one of the main mechanisms for the implementation of excitatory synaptic inputs in the nervous system.

Postsynaptic potentials (PSPs) are electrical reactions in the post-synaptic space of the postsynaptic membrane. The postsynaptic membrane is located behind the presynaptic membranes and is part of the synapse. There, interaction occurs between nerve impulses and synaptic potentials. There are two types of PSP: excitatory and inhibitory. They arise due to endogenous and exogenous electrical activity, the generation of action potentials and structural changes caused by the process of electrotonic charge entry through the slit diaphragm. Excitatory potentials include action potentials and associated short-term positive postsynaptic currents, as well as hyperpolarization that occurs on the postsynaptic membranes of nerve cells, i.e. upon contact with voltage-gated ion channels. The central object of study of the structure and functioning of the nervous system, in particular synapses, is the dynamic mathematical apparatus of neurophysiology - the foundations of the mathematical theory of electrical and electromagnetic phenomena,