Roman's symptom (Romapa S Sign)

Roman's Sign

Roman's sign (Roman S Sign) is an early clinical sign of Chagas disease. It appears approximately 3 weeks after infection and is characterized by significant swelling of the eyelids of one or both eyes.

This inflammation can occur for two reasons:

  1. Due to the presence of the parasite Trypanosoma cruzi in the body, which causes the development of Chagas disease. These parasites attack tissues and organs, including the eyes, causing an inflammatory response.

  2. As a manifestation of an allergic reaction to constant bites of infected reduvid insects, which are carriers of the T. cruzi parasite. Their saliva contains antigens that provoke the development of eyelid edema.

Thus, the Roman symptom is an important early marker of Chagas disease, allowing one to suspect this disease even before the appearance of other symptoms and begin treatment in a timely manner.



Roman's sign is an early clinical sign of Chagas disease, appearing approximately 3 weeks after infection. It is characterized by significant swelling of the eyelids of one or both eyes. Such swelling may be due to the presence of parasites in the body that cause the development of this disease, or it may be a manifestation of an allergic reaction to constant bites of blood-sucking insects - virus carriers.

Chagas disease belongs to a group of vector-borne diseases spread by a human carrier (reservoir) of the virus, mainly through a blood-sucking insect (triatomine bug). IN



Roman-Sinding syndrome (Romaipas sign) is a rare diagnosis and is one of the first signs of Chagas disease, and although in our country this syndrome cannot be observed so clearly due to the absence of carriers of this infection in our climate zone (for example, hemosucker mosquitoes), however, based on many known signs, I was able to compare the same symptom with infectious mononucleosis in our strange African



Chagas disease is one of the most dangerous diseases in South America. It arises from the blood and other parasites of infected animals. This leads to different types of symptoms, and one of them is Roman's symptom. It is characterized by severe inflammation on one or both eyelids.

This is an early symptom that appears within three weeks of infection. The symptom appears as severe swelling on the eyelids of one or both eyes. Swelling can also spread to surrounding tissues and may cause eye pain.

Possible causes of Roman's symptom are infection caused by Chagas disease, as well as allergies to insect bites with the virus. In this case, the symptom can occur both in infected people and in healthy people. In the latter case, it is usually associated with insect bites.

It should be noted that Roman’s symptom can cause certain difficulties in diagnosing Chagas disease in the patient himself. On the one hand, a swollen eyelid with the development of the disease quite often accompanies other symptoms associated with this infection, for example, abdominal pain. On the other hand, the diagnosis of the disease depends not only on this sign, but also on a certain blood picture. Therefore, the doctor must pay attention to this symptom along with other clinical signs.