Sepsis Pirogova-Pasteira-Listera

Sepsis is a serious disease that occurs when an infection enters the bloodstream and causes a strong inflammatory response in the body. Sepsis can lead to various complications such as infection, shock, kidney failure and even death. However, there are methods that can reduce the risk of developing sepsis and increase the effectiveness of treatment for this disease.

Sepsis or pie-Lister fever is a general concept that reflects the danger and acute severity of toxic changes or intoxications observed in the body. This term has been widely used to date in medical practice and is used to characterize the combination of infectious diseases of a purulent nature with severe fever. Its appearance in acute disseminated primary purulent infection (phlegmon) or pyemic tissue diseases is caused by an imbalance between toxic and protective factors in the body. The diagnosis of “sepsis” is a borderline state between “somatic pathology” and “infectious disease”.

The classical concept of sepsis is based on three criteria: the presence of bacteria in the blood, severe bacterial intoxication and changes in the hemostatic system. In turn, septic hemoconcentration is also interconnected with the destruction of the body’s immunological reactivity, since one of the reasons for the formation of sepsis is autointoxication with waste products of pathogenic microorganisms, which is realized through disruption of the interaction of immunocompetent cells. The main aspects of this mutual influence are illustrated by the infectious-dissociative syndrome of sepsis, which develops according to two mechanisms:

1. The first is the development of a chronic or latent infection when a macroorganism is infected with a virulent microorganism, as well as the use of immunosuppressive therapy or induced immunodeficiencies. With this mechanism of exacerbation of infections of varying duration, they arise under the influence of various provoking factors (surgery, etc.). In this case, immunocytes are not able to exhibit protective functions, ensuring “the occurrence and maintenance of sepsis with high activity of sepsis itself.” These situations are characterized by stages and phases that do not differ from each other in clinical manifestations and are in a reversible state; 2. The second mechanism for the development of sepsis is associated with acute infection, especially occurring when the immune defense is unsatisfactory and the human body has an inadequate response. In this case, the patient’s own protein metabolism can lead to a sharp increase in the virulent properties of microorganisms. This form of inflammation