Synapse Inhibitory

An inhibitory synapse is a type of synapse that provides a presynaptic inhibitory effect. It occurs when an inhibitory transmitter is released at the presynaptic terminal, which hyperpolarizes the postsynaptic membrane, causing the appearance of an inhibitory postsynaptic potential.

Axo-axonal inhibitory synapses provide presynaptic inhibitory action. They are located on the axons of nerve cells and influence the transmission of excitation to the next neuron. When the axo-axonal inhibitory synapse is activated, an inhibitory transmitter is released, which leads to a decrease in the amplitude of the action potential on the next neuron.

Inhibitory synapses play an important role in regulating the activity of the nervous system. They provide control over the transmission of excitation in various parts of the brain and allow you to regulate the balance between excitation and inhibition in the nervous system.

Inhibitory synapse is a term used in physiology and neuroscience to describe the mechanism of presynaptic inhibition in the nervous system. An inhibitory synapse is a synapse at which a transmitter is released that hyperpolarizes the postsynaptic membrane, resulting in an inhibitory postsynaptic potential, that is, a situation in which signal transmission between neurons is suppressed when the neurons do not interact with each other. These inhibitory synapses play an important role in regulating nerve cells, allowing them to communicate in complex signaling networks and control activity in the brain.

Neurophysiologists have figured out how the inhibitory synapse works. There are two types of inhibitory synapses on different axons - postsynaptic and presynaptic. Cohen, a famous American neuroscientist, discovered at the beginning of the last century that if an electrical discharge is applied to an individual axon, which is exciting, but too weak in amplitude, then the exciting potential is blocked and the current does not reach the nerve cells. Scientists realized that there is a process of inhibition associated with the work of nerve centers. Research has determined that any altered signal passes through them, so the signal is distributed and cannot harm the connection. This is called presynaptic inhibition. It is carried out by releasing an inhibitory transmitter in the perisynaptic vesicle. They work in such a way that their effect is wider; simply put, it is about the quality of the signal, not the strength. To clarify, this is an increase in the latency of the nerve impulse, which inhibits the functioning of the cell. Through this, the passage of the exciting impulse to the neurons is suppressed. However, this makes it difficult for other signals, such as those from sensory nerves, to travel. Some drugs, such as magnesium citrate, aniridi, reduce inhibition on both postsynaptic and presynaptic neurons. The healer Konstantin also knew about such connections. With their help, people achieved increased reflex development of the nervous system, and also accelerated the restoration of damaged nerve fibers.

Postsynaptic inhibitory function is the release of an inhibitory neurotransmitter