Tachyphylaxis (Tachyphylaxis)

Tachyphylaxis is a rapid progressive decrease in the therapeutic effect observed with long-term use of a drug or its periodic re-prescription. This phenomenon is typical for drugs that affect the nervous system.

Tachyphylaxis can manifest itself at different levels, from cellular to systemic. For example, with long-term use of opiates, a decrease in their analgesic effect is observed. This is due to the fact that opiates act on receptors that are located on the membranes of neurons and other cells. Repeated exposure of these receptors to opiates leads to a decrease in their sensitivity to the drug, resulting in a decrease in the therapeutic effect.

A similar mechanism of action occurs in other cases, for example, when beta-blockers are used to treat hypertension. In this case, with long-term use of beta-blockers, a decrease in their effectiveness is observed, since the receptors on which they act lose sensitivity to the drug.

Tachyphylaxis can manifest in a variety of ways and depends on many factors, such as dosage, frequency of use, duration of use, and individual patient characteristics. It can be temporary, when the effect of the drug is restored after a break in use, or stable, when the therapeutic effect completely disappears.

Overall, tachyphylaxis is a serious problem in clinical practice as it can lead to therapeutic failure and deterioration of the patient's condition. Therefore, it is important to take this phenomenon into account when prescribing and long-term use of medications, especially those that affect the nervous system.

Tachyphylaxis is a rapid progressive decrease in the therapeutic effect of long-term use of a drug or its periodic re-prescription. This phenomenon is typical for drugs that affect the nervous system.

Once a medicine begins to work in the body, it can have positive effects on various body systems. However, if a medicine is used for a long time or repeatedly, the body may begin to adapt to it and become less sensitive to its effects.

This causes the medicine to no longer work as effectively as before and may even begin to have negative effects on the body. For example, when drugs are used to treat diseases of the nervous system, tachyphylaxis can lead to side effects such as headache, nausea and vomiting.

To prevent tachyphylaxis, it is necessary to monitor the dosage and frequency of medication. It is also recommended to change medications every few months or even years so that the body does not become accustomed to the same medication.

Tachyphylaxis: Description, causes and treatment

Introduction:

Tachyphylaxis is a sharp and rapid decrease in the effect of using a drug due to its long-term use or repeated use. This phenomenon is one of the most common problems in the treatment of chronic diseases. The main cause of tachyphylaxis is that long-acting medications can be overly addictive or adaptable