Postsynaptic inhibition

Postsynaptic inhibition is inhibition caused by hyperpolarization of the postsynaptic membrane.

During postsynaptic inhibition, inhibitory neurons are activated, which release transmitters into the synaptic cleft. These mediators interact with receptors on the postsynaptic membrane, which leads to the opening of ion channels and an increase in membrane permeability for potassium ions.

As a result, potassium ions leave the cell and hyperpolarization of the membrane occurs. The hyperpolarized membrane becomes less excitable, that is, inhibition occurs.

Thus, during postsynaptic inhibition, suppression of the excitability of a nerve cell occurs due to the direct effect of inhibitory mediators on the postsynaptic membrane, causing its hyperpolarization. This mechanism plays an important role in regulating excitation processes in the nervous system.

Postsynaptic inhibition and its significance for the nervous system

Post-synaptic inhibition is a process that occurs at nerve synapses and is associated with a change in the electrical activity of the postsynaptic membranes of neurons. This phenomenon is important for the functioning of the nervous system and the regulation of its activity.

Inhibition of neural activity occurs due to hyperpolarization of the postsynaptic membrane. This effect can be caused by various factors, such as the entry of large amounts of potassium or calcium ions into the space between the postsynaptic and presynaptic membranes. Potassium is the main intracellular ion that regulates neuron membrane potential, and calcium plays an important role in the transmission and contraction of nerve impulses. When these ions move into the postsynaptic vesicle and hyperpolarize the postsynaptic membrane, this leads to a decrease in the rate of excitation transmission and subsequent inhibition of neural activity.

Braking value