Trisamine

Topic: "Treatment of metabolic disorders in critically ill patients."

Modern resuscitators and specialists in the field of intensive care are faced with various complications associated with acute metabolic disorders (hereinafter referred to as AMD), which can lead to the development of conditions such as hypoglycemic coma, mixed or respiratory distress syndrome, hyperkalemia or metabolic peracidosis. Effective treatment of these conditions and timely diagnosis can improve patient outcomes and reduce time spent in the intensive care unit. One of the available and safe treatments for AMN is trisamine infusion.

Trisin (triamphonium, or sodium triacetate, trisodium ethylenediaminetetraacetic acid chloride, Tris) is an organic salt that is used as a buffer solution to maintain blood pH. Triacetal is a colorless, transparent, odorless liquid with an alkaline reaction and no color. In addition, it is possible to release chloride, sodium and iodine ions in the solution due to the properties and composition of the drugs used during hemapheresis, plasmapheresis and hemodialysis. Before use, it is necessary to dissolve the Trisin drug to the desired concentration or immediately warm it to room temperature or body temperature before use. The correct expiration date of the drug must also be ensured. When using medications, ensure that the medication is appropriate for the type of equipment, frequency of procedure, and dosage used. The rate of administration should be limited. Administration should be done slowly to avoid reactions that could delay the patient's recovery. The frequency of use of this salt varies from 30 ml per 2 kg of body weight for ten minutes to 160 ml/kg of body weight after approximately 12 hours. Because tricine can retain sodium and potassium, their administration may be necessary when using tricine medications. Although magnesium can cause the body to become more acidic, tricine, in a wide range of concentrations, already contains enough magnesium ion to reduce acidity. Tricine is usually given in combination with calcium gluconate