Vero-Cisplatin: characteristics of the drug
Vero-Cisplatin is a drug belonging to the pharmacological group of alkylating agents, platinum derivatives. The drug is manufactured in India by Ocasa Pharma and has the international name Cisplatin. Vero-Cisplatin contains the active ingredient cisplatin.
The dosage form of Vero-Cisplatin is presented as an injection solution with a concentration of 10 mg/20 ml and a concentrate for the preparation of an infusion solution with a concentration of 0.5 mg/ml.
The drug is indicated for the treatment of metastatic ovarian and testicular cancer, bladder, cervical, lung, head and neck cancer.
Vero-Cisplatin is contraindicated in case of hypersensitivity to the components of the drug, insufficiency of kidney and bone marrow function, hearing impairment, pregnancy and breastfeeding.
When using Vero-Cisplatin, side effects are possible, such as renal dysfunction with increased levels of creatinine and uric acid in the blood serum, nausea, vomiting, anorexia, hearing loss, taste disturbance, peripheral neuropathy, convulsive syndrome, myelosuppression, changes in electrolyte balance, increased transaminase levels, allergic, including anaphylactic reactions.
You should also consider possible interactions of Vero-Cisplatin with other drugs. The drug is incompatible with nephrotoxic drugs (for example, aminoglycosides, etc.). Mannitol may reduce urinary excretion of the drug.
There is no information available in case of overdose with Vero-Cisplatin. However, before starting treatment, it is recommended to administer an infusion (over 8-12 hours) of 1-2 liters of 5% dextrose or saline to reduce nephrotoxicity. Adequate hydration and diuresis (mannitol with furosemide) are necessary for the next 24 hours. During therapy, the function of the kidneys, hearing organs and central nervous system should be monitored.
Thus, Vero-Cisplatin is an effective drug for the treatment of various types of cancer, but its use should be under the supervision of a qualified physician, taking into account all contraindications, side effects and possible interactions with other drugs.