Addison-Beermer Disease

Addison-Biermer Disease: Understanding, Symptoms and Treatment

Addison-Beermer disease, also known as pernicious anemia, is a rare and serious disease that is characterized by insufficiency of endocrine adrenal function and anemia caused by vitamin B12 deficiency. This disease was named after two prominent doctors who made significant contributions to its study and description: Thomas Addison and Albrecht Biermer.

Thomas Addison, an English physician, first described the clinical signs and symptoms of the disease in 1855. He noted that patients with this condition experience chronic weakness, fatigue, skin hyperpigmentation (due to increased melanin levels), and decreased appetite and weight. Albrecht Birmer, a Swedish physician, later linked these symptoms to vitamin B12 deficiency, which leads to impaired blood formation and the development of anemia.

The main cause of Addison-Birmer disease is an autoimmune lesion of the gastrointestinal tract, which leads to impaired absorption of vitamin B12. Vitamin B12 is necessary for the normal formation of red blood cells and the functioning of the nervous system. When it is deficient, DNA synthesis and cell division are disrupted, which leads to anemia and nervous disorders.

The main symptom of Addison-Birmer disease is anemia, which develops gradually and is manifested by fatigue, weakness, shortness of breath and palpitations. Patients also experience decreased appetite, weight loss, increased irritability, and decreased concentration. A characteristic feature of this disease is hyperpigmentation of the skin, especially on open areas of the body, as well as on the mucous membranes.

Diagnosis of Addison-Biermer disease uses a variety of methods, including blood tests to measure levels of vitamin B12 and folic acid, examination of the gastrointestinal tract through endoscopy and biopsy, and measurement of antibodies to intrinsic factor Castle-Intrup, which plays a key role in absorption of vitamin B12.

Treatment of Addison-Birmer disease is aimed at eliminating vitamin B12 deficiency and maintaining normal levels of this vitamin in the body. The main treatment method is the administration of vitamin B12 through injections or taking special medications orally. Vitamin B12 may also be given as a nasal spray or under the tongue for better absorption.

Patients with Addison-Birmer disease may require regular vitamin B12 injections throughout their lives. This helps prevent the development of anemia and decreased nervous system function. In addition to vitamin B12, other medications may be prescribed to improve symptoms and keep the patient healthy.

It is important to note that early diagnosis and initiation of treatment for Addison-Biermer disease plays a critical role in the prognosis and improvement of the patient's quality of life. Regular consultation with your doctor and adherence to prescribed treatment will help control symptoms and prevent complications.

In conclusion, Addison-Biermer disease is a serious condition that is characterized by adrenal insufficiency and vitamin B12 deficiency. Early detection and treatment of this disease is essential to maintaining the patient's health. With constant medical supervision and the right therapy, people suffering from Addison-Biermer disease can live full and active lives.

Addison-Biermer disease is a serious disease that is associated with disruption of the adrenal glands. The cause of the disease is an autoimmune process in which the body begins to attack its own cells. Research shows that about 8% of all cases are associated with an infection, such as a bacterial, viral or fungal infection. In rare cases, a genetic predisposition may be the cause.

Symptoms of Addison-Birmer's disease can manifest in different ways and depend on the stage of the disease. The most common symptoms include weakness, decreased appetite, weight loss, mood changes, sleep disturbances, fatigue, muscle pain, hypoglycemia, and others. In addition, due to disruption of the adrenal glands, an increase in blood pressure and heart rate is observed.