Aerran

Country of origin: Puerto Rico

Pharm-Group: Inhalation anesthesia products

Manufacturers: Baxter Healthcare Corporation (Puerto Rico)

International name: Isoflurane

Synonyms: Foran

Dosage forms: liquid for inhalation anesthesia

Composition: Active substance: Isoflurane.

Indications for use: Inhalation anesthesia.

Contraindications: Hypersensitivity, genetic susceptibility to malignant hyperthermia.

Side effects: In the induction phase: cough, difficulty breathing, laryngospasm; in the anesthesia phase - respiratory depression, hypotension, rhythm disturbances; in the postoperative period - mild chills, nausea, vomiting, intestinal obstruction, liver dysfunction, intellectual and mental disorders (2-3 days after anesthesia), worsening mood (within 6 days), leukocytosis, transient increase in glucose, creatinine, nitrogen levels urea, cholesterol and alkaline phosphatase, malignant hyperthermia syndrome associated with hypercatabolic processes in skeletal muscles and a sharp increase in oxygen consumption, manifested by muscle rigidity, tachycardia, increased respiratory movements, cyanosis, rhythm disturbances, instability of blood pressure; decreased partial pressure of oxygen and pH, hyperkalemia, base deficiency; renal failure.

Interaction: The combination with nitrous oxide reduces the minimum alveolar concentration required for anesthesia, while the severity of arterial hypotension also decreases. Potentiates the effect of muscle relaxants, especially the non-depolarizing type.

Overdose: No data available.

Special instructions: Use only under the supervision of an anesthesiologist. Careful monitoring of respiratory function is necessary. In patients with coronary artery disease, maintaining normal hemodynamic parameters is especially important to prevent myocardial ischemia. A transient increase in cerebrospinal fluid pressure in the stage of deep anesthesia is corrected by hyperventilation. The use of isoflurane anesthesia for abortion may be accompanied by increased blood loss.

Literature: Encyclopedia of Medicines, 2006.