Diover

Country of origin: Croatia
Pharm-Group: Loop diuretics

Manufacturers: Pliva Hrvatska d.o.o. (Croatia)
International name: Torasemide
Dosage forms: 5 mg tablets, 10 mg tablets
Composition: Active substance - Torasemide.

Indications for use: Edema caused by heart failure, liver, kidney and lung diseases

Contraindications: Hypersensitivity to torasemide and sulfonamides, anuria, hepatic coma and precomatous state, renal failure with increasing azotemia, arterial hypotension, arrhythmias, pregnancy, lactation, age under 18 years. With caution: with a predisposition to hyperuricemia, with gout, with latent and severe diabetes mellitus.

Side effects: From the blood: in some cases, changes in the blood picture may be observed: a decrease in the number of red blood cells, leukopenia, thrombocytopenia. On the part of the cardiovascular hematopoietic system: in some cases, due to blood thickening, circulatory disorders and thromboembolism occur, and a decrease in blood pressure. From the digestive tract: various dysfunctions of the digestive tract, loss of appetite, dry mouth; rarely - pancreatitis. From the kidneys and urinary tract: in patients with urinary tract obstruction, urinary retention may occur; sometimes - an increase in urea and creatinine levels. From the central nervous system: headache, pain, dizziness, weakness, drowsiness, confusion, convulsions, and paresthesia of the extremities. From the liver: increased levels of liver enzymes may be observed. Changes in laboratory parameters: hypovolemia, water and electrolyte imbalance, hypokalemia, increased levels of uric acid in the blood serum, hyperglycemia and hyperlipidemia. Allergic reactions: skin itching, rashes and photosensitivity. From the senses: visual impairment, tinnitus, deafness.

Interaction:

Torsemide increases the sensitivity of the myocardium to cardiac glycosides in case of potassium or magnesium deficiency. When taken simultaneously with mineralocorticoids, glucocorticoids, and laxatives, potassium excretion may increase. Torsemide enhances the effect of antihypertensive drugs. In high doses, it can enhance the nephro- and ototoxic effects of aminoglycoside antibiotics, the toxicity of cisplatin preparations, the nephrotoxic effects of cephalosporins, the cardio- and neurotoxic effects of lithium preparations.

Torsemide may enhance the effect of curare-containing muscle relaxants and theophylline. When using large doses of salicylates, their toxic effect may be enhanced. Torsemide may reduce the effectiveness of hypoglycemic (antidiabetic) agents. Sequential or simultaneous use of torasemide with ACE inhibitors may lead to a transient drop in blood pressure. This can be avoided by reducing the initial dose of the ACE inhibitor or reducing the dose of torasemide (or temporarily stopping it). NSAIDs may reduce the diuretic and hypotensive effects of torsemide; cholestyramine may reduce the absorption of torasemide from the gastrointestinal tract.

Overdose: No data available.

Special instructions:

During long-term treatment with Diuver, it is recommended to monitor electrolyte balance, glucose, uric acid, creatinine and blood lipids. Before prescribing Diuver, the water and electrolyte balance should be corrected. Use with caution if you have gout or tend to increase uric acid levels. If you have type 1 or type 2 diabetes, you need to monitor your blood glucose levels. During treatment with Diuver, you must refrain from driving vehicles and engaging in activities that require concentration.

Literature:

1. Instructions for medical use of the drug "Diuver".
2. Prospectus of the manufacturer.