Dominici Okraska

**Dominic staining** is one of the methods for examining tissues for the presence of malignant cells or other pathological changes. This method is used in oncology and other areas of medicine to diagnose and monitor the course of diseases.

**The Dominici Method** was first proposed by the French physician Jules Dominicot, who died in 1926. His method involves staining tissues with specific dyes such as Giemsa or Schmelza to make microscopic examination clearer and more transparent. After staining, the tissue is placed under a microscope, where it is illuminated with special blue or ultraviolet light.

Dominici staining is one of the main methods of microscopy in medicine and biology. It is used to determine the presence and type of cancer cells in the body. This type of staining allows the identification of metastatic cells, which may be scattered throughout the body and difficult to detect. This method can also identify the presence of infections and other pathogenic organisms.

During Dominici staining, tissues are stained with special dyes and then carefully examined under a microscope. In this case, areas of tissue infiltration by malignant cells are detected, as well as the possibility of identifying widespread metastases. An important point of the Dominici method is its simplicity and ease of implementation, as well as absolute transparency and clarity of the painted areas.

One of the main advantages of the Dominici method is the ability to detect tumors even at small sizes (1 mm). In some cases, such tissues may be normal for histological evaluation. Sometimes staining using this method allows specialists to make the correct diagnosis and prescribe the correct treatment for the patient in a timely manner. However, there are several disadvantages of coloring using this method - in the case of using some dyes, the tissue under microscopy looks paler than the real one, which can cause specialists to mistrust the results. Another significant disadvantage of this method is the inaccuracy of detection of metastatic and infectious tissues.