Гемосидероз (Haemosiderosis)

Hemosiderosis is a disease associated with excessive accumulation of iron in the body. This situation occurs as a result of excess iron intake or the prescription of iron supplements in large doses (most often during a blood transfusion).

With hemosiderosis, iron is deposited in tissues in the form of hemosiderin and ferritin. This leads to damage to various internal organs, including the heart, liver, spleen, pancreas and others. The accumulation of iron in tissues disrupts their normal functioning.

Hemosiderosis differs from hemochromatosis in that with hemochromatosis, excessive accumulation of iron occurs due to impaired metabolism of this microelement. Hemosiderosis develops as a complication after multiple blood transfusions, taking iron supplements or prolonged contact with iron compounds.

Thus, hemosiderosis is a serious disease that requires timely diagnosis and adequate treatment to prevent irreversible changes in internal organs.

Hemosiderosis is a disease associated with excessive accumulation of iron in the body. This situation occurs as a result of excess iron intake or the administration of iron supplements in large doses, most often during a blood transfusion. Hemosiderosis leads to damage to various internal organs, including the heart and liver.

Iron is an essential trace element necessary for the normal functioning of the body. It plays a key role in the process of hematopoiesis and ensures the delivery of oxygen to various tissues and organs. However, when iron levels in the body become too high, there is a risk of developing hemosiderosis.

Hemosiderosis can be caused by several factors. One cause is a genetic disorder of iron metabolism known as hemochromatosis. Hemochromatosis is a more serious disease than hemosiderosis, and is characterized by dysregulation of the absorption and excretion of iron by the body. As a result, iron begins to accumulate in various tissues and organs, causing them to become damaged.

In hemosiderosis, unlike hemochromatosis, excessive accumulation of iron occurs due to external factors, such as long-term use of iron supplements or frequent blood transfusions. Iron supplements are usually prescribed to treat anemia or other conditions associated with low iron levels in the body. However, if used incorrectly or in excess dosage, they can lead to hemosiderosis.

Hemosiderosis can lead to serious consequences for the body. Excessive iron accumulation causes damage to tissues and organs, especially the heart, liver and spleen. Siderophagy gradually develops - the process of eating and recycling damaged red blood cells, which leads to the formation of characteristic pigment deposits called siderochrome. Siderochrome can accumulate in various organs, causing their dysfunction and deterioration of the patient’s general condition.

Symptoms of hemosiderosis can vary depending on the organs affected, but may include fatigue, general weakness, shortness of breath, abdominal pain, enlarged liver and spleen, arrhythmia and other cardiovascular disorders. The diagnosis of hemosiderosis is usually based on an analysis of iron levels in the body, a biopsy of affected tissue, and the patient's clinical symptoms.

Treatment of hemosiderosis is aimed at reducing iron levels in the body and preventing further accumulation. It may include phlebotomy, a procedure to remove excess iron by periodically reducing the body's blood volume through transfusions or using iron chelators, which bind iron and help remove it from the body.

It is important to note that treatment for hemosiderosis must be prescribed and supervised by a qualified medical specialist. Self-medication or improper treatment can lead to serious complications and deterioration of the patient's condition.

In conclusion, hemosiderosis is a disease characterized by excessive accumulation of iron in the body. It can be caused by excess iron intake or the prescription of iron supplements in large doses. Hemosiderosis leads to damage to various organs, especially the heart and liver. Early detection, diagnosis and timely treatment of hemosiderosis are important steps to prevent progression of the disease and minimize its complications.

Hemosiderosis is a disorder of iron metabolism. An excess of the element leads to the appearance of hemosiderin. Both words are synonyms.

Hemosiderin is deposited in tissues with: * hereditary predisposition to the disease; * excess iron intake from food or medications; * blood transfusion to a patient; * acute, chronic poisoning with lead or chromium; * kidney diseases; * deficiency of vitamins C, B12, B9 and copper; * oncological diseases.

Renal sodium and phosphate congestion is a common cause of the formation of an “abnormal” iron-protein complex. The disorder is associated with oxidative stress, which promotes the removal of ions from the bloodstream.

Immunity disorders are often observed in patients with hemosiderosis. The body's immunocompetent cells attack themselves, affecting elements of the digestive tract, testicles and bone marrow. In such cases, the hematologist uses immunosuppressive therapy.